Molecular dissection of a major gene effect on a quantitative trait: the level of alcohol dehydrogenase expression in Drosophila melanogaster - PubMed (original) (raw)
Molecular dissection of a major gene effect on a quantitative trait: the level of alcohol dehydrogenase expression in Drosophila melanogaster
L F Stam et al. Genetics. 1996 Dec.
Abstract
A molecular mapping experiment shows that a major gene effect on a quantitative trait, the level of alcohol dehydrogenase expression in Drosophila melanogaster, is due to multiple polymorphisms within the Adh gene. These polymorphisms are located in an intron, the coding sequence, and the 3' untranslated region. Because of nonrandom associations among polymorphisms at different sites, the individual effects combine (in some cases epistatically) to produce "superalleles" with large effect. These results have implications for the interpretation of major gene effects detected by quantitative trait locus mapping methods. They show that large effects due to a single locus may be due to multiple associated polymorphisms (or sequential fixations in isolated populations) rather than individual mutations of large effect.
Similar articles
- The effect of an intronic polymorphism on alcohol dehydrogenase expression in Drosophila melanogaster.
Laurie CC, Stam LF. Laurie CC, et al. Genetics. 1994 Oct;138(2):379-85. doi: 10.1093/genetics/138.2.379. Genetics. 1994. PMID: 7828821 Free PMC article. - Associations between DNA sequence variation and variation in expression of the Adh gene in natural populations of Drosophila melanogaster.
Laurie CC, Bridgham JT, Choudhary M. Laurie CC, et al. Genetics. 1991 Oct;129(2):489-99. doi: 10.1093/genetics/129.2.489. Genetics. 1991. PMID: 1683848 Free PMC article. - Synergistic effect of Adh alleles in Drosophila melanogaster.
Li XM. Li XM. Proc Biol Sci. 1992 Jan 22;247(1318):9-16. doi: 10.1098/rspb.1992.0002. Proc Biol Sci. 1992. PMID: 1348124 - Analysis of the gene encoding the multifunctional alcohol dehydrogenase allozyme ADH-71k of Drosophila melanogaster.
Eisses KT, Andriesse AJ, Douwe de Boer A, Thörig GE, Weisbeek PJ. Eisses KT, et al. Mol Biol Evol. 1990 Sep;7(5):459-69. doi: 10.1093/oxfordjournals.molbev.a040614. Mol Biol Evol. 1990. PMID: 2124644 - Worldwide latitudinal clines for the alcohol dehydrogenase polymorphism in Drosophila melanogaster: what is the unit of selection?
van Delden W, Kamping A. van Delden W, et al. EXS. 1997;83:97-115. doi: 10.1007/978-3-0348-8882-0_6. EXS. 1997. PMID: 9342845 Review.
Cited by
- A SNP variation in the Sucrose synthase (SoSUS) gene associated with sugar-related traits in sugarcane.
Khanbo S, Somyong S, Phetchawang P, Wirojsirasak W, Ukoskit K, Klomsa-Ard P, Pootakham W, Tangphatsornruang S. Khanbo S, et al. PeerJ. 2023 Dec 15;11:e16667. doi: 10.7717/peerj.16667. eCollection 2023. PeerJ. 2023. PMID: 38111652 Free PMC article. - Genetic basis of speciation and adaptation: from loci to causative mutations.
Kitano J, Ishikawa A, Ravinet M, Courtier-Orgogozo V. Kitano J, et al. Philos Trans R Soc Lond B Biol Sci. 2022 Jul 18;377(1855):20200503. doi: 10.1098/rstb.2020.0503. Epub 2022 May 30. Philos Trans R Soc Lond B Biol Sci. 2022. PMID: 35634921 Free PMC article. - The genetic architecture of temperature adaptation is shaped by population ancestry and not by selection regime.
Otte KA, Nolte V, Mallard F, Schlötterer C. Otte KA, et al. Genome Biol. 2021 Jul 16;22(1):211. doi: 10.1186/s13059-021-02425-9. Genome Biol. 2021. PMID: 34271951 Free PMC article. - Predicting future from past: The genomic basis of recurrent and rapid stickleback evolution.
Roberts Kingman GA, Vyas DN, Jones FC, Brady SD, Chen HI, Reid K, Milhaven M, Bertino TS, Aguirre WE, Heins DC, von Hippel FA, Park PJ, Kirch M, Absher DM, Myers RM, Di Palma F, Bell MA, Kingsley DM, Veeramah KR. Roberts Kingman GA, et al. Sci Adv. 2021 Jun 18;7(25):eabg5285. doi: 10.1126/sciadv.abg5285. Print 2021 Jun. Sci Adv. 2021. PMID: 34144992 Free PMC article. - Fitness effects but no temperature-mediated balancing selection at the polymorphic Adh gene of Drosophila melanogaster.
Siddiq MA, Thornton JW. Siddiq MA, et al. Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21634-21640. doi: 10.1073/pnas.1909216116. Epub 2019 Oct 8. Proc Natl Acad Sci U S A. 2019. PMID: 31594844 Free PMC article.
References
- Genetics. 1987 Jan;115(1):129-40 - PubMed
- Proc Natl Acad Sci U S A. 1988 Jul;85(14):5161-5 - PubMed
- Genetics. 1991 Oct;129(2):481-8 - PubMed
- Cell. 1983 May;33(1):125-33 - PubMed
- Am J Hum Genet. 1992 Jan;50(1):208-21 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases