CREB phosphorylation and dephosphorylation: a Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression - PubMed (original) (raw)
CREB phosphorylation and dephosphorylation: a Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression
H Bito et al. Cell. 1996.
Free article
Abstract
While changes in gene expression are critical for many brain functions, including long-term memory, little is known about the cellular processes that mediate stimulus-transcription coupling at central synapses. In studying the signaling pathways by which synaptic inputs control the phosphorylation state of cyclic AMP-responsive element binding protein (CREB) and determine expression of CRE-regulated genes, we found two important Ca2+/calmodulin (CaM)-regulated mechanisms in hippocampal neurons: a CaM kinase cascade involving nuclear CaMKIV and a calcineurin-dependent regulation of nuclear protein phosphatase 1 activity. Prolongation of the synaptic input on the time scale of minutes, in part by an activity-induced inactivation of calcineurin, greatly extends the period over which phospho-CREB levels are elevated, thus affecting induction of downstream genes.
Similar articles
- Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex.
Anderson KA, Noeldner PK, Reece K, Wadzinski BE, Means AR. Anderson KA, et al. J Biol Chem. 2004 Jul 23;279(30):31708-16. doi: 10.1074/jbc.M404523200. Epub 2004 May 13. J Biol Chem. 2004. PMID: 15143065 - Postsynaptic calcineurin activity downregulates synaptic transmission by weakening intracellular Ca2+ signaling mechanisms in hippocampal CA1 neurons.
Wang JH, Kelly PT. Wang JH, et al. J Neurosci. 1997 Jun 15;17(12):4600-11. doi: 10.1523/JNEUROSCI.17-12-04600.1997. J Neurosci. 1997. PMID: 9169521 Free PMC article. - Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity.
Deisseroth K, Bito H, Tsien RW. Deisseroth K, et al. Neuron. 1996 Jan;16(1):89-101. doi: 10.1016/s0896-6273(00)80026-4. Neuron. 1996. PMID: 8562094 - [A study on the role and mechanism of intracellular Ca2+ in the central nervous system].
Miyamoto E. Miyamoto E. Nihon Yakurigaku Zasshi. 1990 Oct;96(4):141-52. doi: 10.1254/fpj.96.4_141. Nihon Yakurigaku Zasshi. 1990. PMID: 2175289 Review. Japanese. - Mechanisms controlling gene expression by nuclear calcium signals.
Hardingham GE, Cruzalegui FH, Chawla S, Bading H. Hardingham GE, et al. Cell Calcium. 1998 Feb-Mar;23(2-3):131-4. doi: 10.1016/s0143-4160(98)90111-7. Cell Calcium. 1998. PMID: 9601608 Review.
Cited by
- Induction of long-term hyperexcitability by memory-related cAMP signaling in isolated nociceptor cell bodies.
Bavencoffe A, Zhu MY, Neerukonda SV, Johnson KN, Dessauer CW, Walters ET. Bavencoffe A, et al. Neurobiol Pain. 2024 Sep 20;16:100166. doi: 10.1016/j.ynpai.2024.100166. eCollection 2024 Jul-Dec. Neurobiol Pain. 2024. PMID: 39399224 Free PMC article. - Decoding Arc transcription: a live-cell study of stimulation patterns and transcriptional output.
Kim DW, Moon HC, Lee BH, Park HY. Kim DW, et al. Learn Mem. 2024 Sep 11;31(8):a054024. doi: 10.1101/lm.054024.124. Print 2024 Aug. Learn Mem. 2024. PMID: 39260877 - Induction of long-term hyperexcitability by memory-related cAMP signaling in isolated nociceptor cell bodies.
Bavencoffe A, Zhu MY, Neerukonda SV, Johnson KN, Dessauer CW, Walters ET. Bavencoffe A, et al. bioRxiv [Preprint]. 2024 Jul 17:2024.07.13.603393. doi: 10.1101/2024.07.13.603393. bioRxiv. 2024. PMID: 39071414 Free PMC article. Updated. Preprint. - The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.
Chin M, Kaeser PS. Chin M, et al. Cell Rep. 2024 Jul 23;43(7):114428. doi: 10.1016/j.celrep.2024.114428. Epub 2024 Jul 11. Cell Rep. 2024. PMID: 38996073 Free PMC article. - Signaling mechanisms underlying activity-dependent integration of adult-born neurons in the mouse olfactory bulb.
Bao S, Romero JM, Belfort BDW, Arenkiel BR. Bao S, et al. Genesis. 2024 Apr;62(2):e23595. doi: 10.1002/dvg.23595. Genesis. 2024. PMID: 38553878 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous