Synaptic currents generated by neuronal acetylcholine receptors sensitive to alpha-bungarotoxin - PubMed (original) (raw)
Synaptic currents generated by neuronal acetylcholine receptors sensitive to alpha-bungarotoxin
Z W Zhang et al. Neuron. 1996 Dec.
Free article
Abstract
Nicotinic acetylcholine receptors are widely distributed throughout the nervous system, but their functions remain largely unknown. One of the most abundant is a class of receptors that contains the alpha 7 gene product, has a high relative permeability to calcium, and binds alpha-bungarotoxin. Here, we report that receptors sensitive to alpha-bungarotoxin, though concentrated in perisynaptic clusters on neurons, can generate a large amount of the synaptic current. Residual currents through other nicotinic receptors are sufficient to elicit action potentials, but with slower rise times. This demonstrates a postsynaptic response for alpha-bungarotoxin-sensitive receptors on neurons and suggests that the functional domain of the postsynaptic membrane is broader than previously recognized.
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