Epidermal differentiation and keratin gene expression - PubMed (original) (raw)
Affiliations
- PMID: 8983083
Review
Epidermal differentiation and keratin gene expression
E Fuchs. Princess Takamatsu Symp. 1994.
Abstract
Epidermal keratinocytes are ideal as a model system for the study of mammalian differentiation because primary cells have a high proliferative capacity and can be cultured under conditions enabling a balance of growth and differentiation. In addition, epidermal keratin genes have been cloned and characterized, and their strong promoters provide a means of high-level expression of transgenes in the epidermis of mice. For these reasons, considerable headway has been made in recent years in the quest to elucidate the biological pathways involved in the control of epidermal growth and differentiation. An understanding of these mechanisms is essential to realizing the potential of epidermal keratinocytes for drug delivery and gene therapy. This paper reviews what is presently known about epidermal growth and differentiation, with emphasis on the expression of epidermal-specific genes.
Similar articles
- A human epidermal differentiation-specific keratin gene is regulated by calcium but not negative modulators of differentiation in transgenic mouse keratinocytes.
Rosenthal DS, Steinert PM, Chung S, Huff CA, Johnson J, Yuspa SH, Roop DR. Rosenthal DS, et al. Cell Growth Differ. 1991 Feb;2(2):107-13. Cell Growth Differ. 1991. PMID: 1712625 - Keratin 10 gene expression during differentiation of mouse epidermis requires transcription factors C/EBP and AP-2.
Maytin EV, Lin JC, Krishnamurthy R, Batchvarova N, Ron D, Mitchell PJ, Habener JF. Maytin EV, et al. Dev Biol. 1999 Dec 1;216(1):164-81. doi: 10.1006/dbio.1999.9460. Dev Biol. 1999. PMID: 10588870 - Constitutive expression of erbB2 in epidermis of transgenic mice results in epidermal hyperproliferation and spontaneous skin tumor development.
Kiguchi K, Bol D, Carbajal S, Beltrán L, Moats S, Chan K, Jorcano J, DiGiovanni J. Kiguchi K, et al. Oncogene. 2000 Aug 31;19(37):4243-54. doi: 10.1038/sj.onc.1203778. Oncogene. 2000. PMID: 10980598 - Diseases of epidermal keratins and their linker proteins.
Uitto J, Richard G, McGrath JA. Uitto J, et al. Exp Cell Res. 2007 Jun 10;313(10):1995-2009. doi: 10.1016/j.yexcr.2007.03.029. Epub 2007 Apr 24. Exp Cell Res. 2007. PMID: 17531221 Free PMC article. Review. - Epidermal differentiation and keratin gene expression.
Fuchs E. Fuchs E. J Cell Sci Suppl. 1993;17:197-208. doi: 10.1242/jcs.1993.supplement_17.28. J Cell Sci Suppl. 1993. PMID: 7511614 Review.
Cited by
- A Novel Synthetic Material, BMM, Accelerates Wound Repair by Stimulating Re-Epithelialization and Fibroblast Activation.
Seo GY, Hyun C, Koh D, Park S, Lim Y, Kim YM, Cho M. Seo GY, et al. Int J Mol Sci. 2018 Apr 11;19(4):1164. doi: 10.3390/ijms19041164. Int J Mol Sci. 2018. PMID: 29641498 Free PMC article. - Human Papillomavirus and the DNA Damage Response: Exploiting Host Repair Pathways for Viral Replication.
Spriggs CC, Laimins LA. Spriggs CC, et al. Viruses. 2017 Aug 18;9(8):232. doi: 10.3390/v9080232. Viruses. 2017. PMID: 28820495 Free PMC article. Review. - Scaffolding proteins in the development and maintenance of the epidermal permeability barrier.
Crawford M, Dagnino L. Crawford M, et al. Tissue Barriers. 2017 Oct 2;5(4):e1341969. doi: 10.1080/21688370.2017.1341969. Epub 2017 Jun 30. Tissue Barriers. 2017. PMID: 28665776 Free PMC article. Review. - Sox4 links tumor suppression to accelerated aging in mice by modulating stem cell activation.
Foronda M, Martínez P, Schoeftner S, Gómez-López G, Schneider R, Flores JM, Pisano DG, Blasco MA. Foronda M, et al. Cell Rep. 2014 Jul 24;8(2):487-500. doi: 10.1016/j.celrep.2014.06.031. Epub 2014 Jul 17. Cell Rep. 2014. PMID: 25043184 Free PMC article. - Protein 4.1R regulates cell adhesion, spreading, migration and motility of mouse keratinocytes by modulating surface expression of beta1 integrin.
Chen L, Hughes RA, Baines AJ, Conboy J, Mohandas N, An X. Chen L, et al. J Cell Sci. 2011 Jul 15;124(Pt 14):2478-87. doi: 10.1242/jcs.078170. Epub 2011 Jun 21. J Cell Sci. 2011. PMID: 21693581 Free PMC article.