Testis-specific expression of a novel human H3 histone gene - PubMed (original) (raw)
. 1996 Dec 15;229(2):301-6.
doi: 10.1006/excr.1996.0375.
Affiliations
- PMID: 8986613
- DOI: 10.1006/excr.1996.0375
Testis-specific expression of a novel human H3 histone gene
O Witt et al. Exp Cell Res. 1996.
Abstract
We have investigated the expression of a recently described, solitary human H3 histone gene. Using RNase protection assays, the corresponding mRNA could only be detected in RNA preparations from human testis, whereas several human cell lines and somatic tissues did not exhibit expression of this gene. In situ hybridization of sections from human testis revealed expression to be confined to primary spermatocytes. In addition to H1t, this novel H3 gene, which is located on chromosome 1, is the second tissue-specific human histone gene that has been found to be expressed solely in the testis.