Humoral and cellular immune response within the subarachnoid space of patients with neurocysticercosis - PubMed (original) (raw)
. 1996 Winter;27(4):513-7.
Affiliations
- PMID: 8987187
Humoral and cellular immune response within the subarachnoid space of patients with neurocysticercosis
L Ostrosky-Zeichner et al. Arch Med Res. 1996 Winter.
Abstract
To study the immune response within the subarachnoid space in patients with neurocysticercosis, we measured the cerebrospinal fluid contents of immunoglobulins A, E, G, and M in 38 patients and the contents of the proinflammatory cytokines TNF-alpha, IL-1b, IL-6 and IFN-gamma in 17 patients. The same measurements were made in 30 neurological patients without inflammatory or immune-mediated disorders. Each immunoglobulin and cytokine, including the gender and age of the patient, was compared by multiple regression analysis with the CSF contents of cells, protein and ELISA for cysticercal antigens. A direct correlation was found of IgM with cell content (p < 0.058) and with ELISA values (p < 0.027); of age with protein content (p < 0.006); of IL-6 with protein content (p < 0.018) and of IL-1b with ELISA values (p < 0.004). An inverse correlation was found of glucose with ELISA values (p < 0.008). A complex function of the immune response within the subarachnoid space was observed: mean values of IgG, IgM, IgE and interleukins 1b and 6 were increased, whereas values of IgA, TNF-alpha and IFN-gamma were similar to those of controls.
Similar articles
- [Intrathecal immune response in meningeosis neoplastica: IgG, IgM, oligoclonal bands and cytokines].
Weller M, Stevens A, Sommer N, Wiethölter H. Weller M, et al. Nervenarzt. 1992 Apr;63(4):213-7. Nervenarzt. 1992. PMID: 1594086 German. - Heterogeneity of humoral immune components in human cysticercosis.
Correa D, Dalma D, Espinoza B, Plancarte A, Rabiela MT, Madrazo I, Gorodezky C, Flisser A. Correa D, et al. J Parasitol. 1985 Oct;71(5):535-41. J Parasitol. 1985. PMID: 3903094 - [Diagnosis of human neurocysticercosis by ELISA-IgG using a purified antigen].
Salinas P, Sandoval L, Rugiero E, Contreras MC. Salinas P, et al. Bol Chil Parasitol. 1996 Jul-Dec;51(3-4):85-90. Bol Chil Parasitol. 1996. PMID: 9302781 Spanish. - [Cytokines in children with immunodeficiencies].
Kowalczyk D. Kowalczyk D. Folia Med Cracov. 1999;40(1-2):5-97. Folia Med Cracov. 1999. PMID: 10909468 Review. Polish. - Systemic inflammatory response to exhaustive exercise. Cytokine kinetics.
Suzuki K, Nakaji S, Yamada M, Totsuka M, Sato K, Sugawara K. Suzuki K, et al. Exerc Immunol Rev. 2002;8:6-48. Exerc Immunol Rev. 2002. PMID: 12690937 Review.
Cited by
- Expression and distribution of Toll-like receptors 11-13 in the brain during murine neurocysticercosis.
Mishra BB, Gundra UM, Teale JM. Mishra BB, et al. J Neuroinflammation. 2008 Dec 12;5:53. doi: 10.1186/1742-2094-5-53. J Neuroinflammation. 2008. PMID: 19077284 Free PMC article. - CC chemokines mediate leukocyte trafficking into the central nervous system during murine neurocysticercosis: role of gamma delta T cells in amplification of the host immune response.
Cardona AE, Gonzalez PA, Teale JM. Cardona AE, et al. Infect Immun. 2003 May;71(5):2634-42. doi: 10.1128/IAI.71.5.2634-2642.2003. Infect Immun. 2003. PMID: 12704138 Free PMC article. - The implantation of Taenia solium metacestodes in mice induces down-modulation of T-cell proliferation and cytokine production.
Hernández-Mendoza L, Molinari JL, Garrido E, Cortés I, Solano S, Miranda E, Tato P. Hernández-Mendoza L, et al. Parasitol Res. 2005 Mar;95(4):256-65. doi: 10.1007/s00436-004-1285-3. Epub 2005 Jan 28. Parasitol Res. 2005. PMID: 15678353
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical
Miscellaneous