Regulation of epidermal differentiation by a Distal-less homeodomain gene - PubMed (original) (raw)

Regulation of epidermal differentiation by a Distal-less homeodomain gene

M I Morasso et al. J Cell Biol. 1996 Dec.

Abstract

The Distal-less-related homeodomain gene Dlx3 is expressed in terminally differentiated murine epidermal cells. Ectopic expression of this gene in the basal cell layer of transgenic skin results in a severely abnormal epidermal phenotype and leads to perinatal lethality. The basal cells of affected mice ceased to proliferate, and expressed the profilaggrin and loricrin genes which are normally transcribed only in the latest stages of epidermal differentiation. All suprabasal cell types were diminished and the stratum corneum was reduced to a single layer. These data indicate that Dlx3 misexpression results in transformation of basal cells into more differentiated keratinocytes, suggesting that this homeoprotein is an important regulator of epidermal differentiation.

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References

1. 1. Nature. 1978 Dec 14;276(5689):729-31 - PubMed
2. 1. Mech Dev. 1994 Dec;48(3):199-215 - PubMed
3. 1. Exp Cell Res. 1986 Sep;166(1):209-19 - PubMed
4. 1. Nature. 1989 Mar 30;338(6214):432-4 - PubMed
5. 1. Curr Opin Cell Biol. 1989 Dec;1(6):1107-15 - PubMed

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