Gen(om)e duplications in the evolution of early vertebrates - PubMed (original) (raw)
Review
Gen(om)e duplications in the evolution of early vertebrates
A Sidow. Curr Opin Genet Dev. 1996 Dec.
Abstract
Phylogenetic analyses and sequence surveys of developmental regulator gene families indicate that two large-scale gene duplications, most likely genome duplications, occurred in ancestors of vertebrates. Relaxed constraints allowed duplicated and thus redundant genes to diverge in a two stage mechanism. Neutral changes dominated at first but then positively selected regulatory changes evolved the novel and increasingly complex vertebrate developmental program.