Virus-induced autoimmune disease - PubMed (original) (raw)
Review
Virus-induced autoimmune disease
M G von Herrath et al. Curr Opin Immunol. 1996 Dec.
Abstract
The breaking of tolerance or unresponsiveness to self-antigens, involving the activation of autoreactive lymphocytes, is a critical event leading to autoimmune diseases. The precise mechanisms by which this can occur are mostly unknown. Viruses have been implicated in this process, among other etiological factors, such as genetic predisposition and cytokine activity. Several ways have been proposed by which a viral infection might break tolerance to self and trigger an autoreactive cascade that ultimately leads to the destruction of a specific cell type or an entire organ. The process termed "molecular mimicry' and the use of transgenic models in which viral and host genes can be manipulated to analyze their effects in causing autoimmunity have been particular focuses for research. For example, there is a transgenic murine model of virus-induced autoimmune disease, in which a known viral gene is selectively expressed as a self-antigen in beta cells of the pancreas. In these mice, insulin-dependent diabetes develops after either a viral infection, the release of a cytokine such as IFN-gamma, or the expression of the costimulatory molecule B7.1 in the islets of Langerhans. Recent studies using this model have contributed to the understanding of the pathogenesis of virus-induced autoimmune disease and have furthered the design and testing of novel immunotherapeutic approaches.
Similar articles
- Using transgenic mouse models to dissect the pathogenesis of virus-induced autoimmune disorders of the islets of Langerhans and the central nervous system.
von Herrath MG, Evans CF, Horwitz MS, Oldstone MB. von Herrath MG, et al. Immunol Rev. 1996 Aug;152:111-43. doi: 10.1111/j.1600-065x.1996.tb00913.x. Immunol Rev. 1996. PMID: 8930670 Review. - Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes.
Seewaldt S, Thomas HE, Ejrnaes M, Christen U, Wolfe T, Rodrigo E, Coon B, Michelsen B, Kay TW, von Herrath MG. Seewaldt S, et al. Diabetes. 2000 Nov;49(11):1801-9. doi: 10.2337/diabetes.49.11.1801. Diabetes. 2000. PMID: 11078446 - Virus-induced autoimmune disease: transgenic approach to mimic insulin-dependent diabetes mellitus and other autoimmune diseases.
Oldstone MB, von Herrath M. Oldstone MB, et al. APMIS. 1996 Oct;104(10):689-97. doi: 10.1111/j.1699-0463.1996.tb04930.x. APMIS. 1996. PMID: 8980618 Review.
Cited by
- Cross-reactive CD8+ T cell responses to tumor-associated antigens (TAAs) and homologous microbiota-derived antigens (MoAs).
Cavalluzzo B, Viuff MC, Tvingsholm SA, Ragone C, Manolio C, Mauriello A, Buonaguro FM, Tornesello ML, Izzo F, Morabito A, Hadrup SR, Tagliamonte M, Buonaguro L. Cavalluzzo B, et al. J Exp Clin Cancer Res. 2024 Mar 20;43(1):87. doi: 10.1186/s13046-024-03004-z. J Exp Clin Cancer Res. 2024. PMID: 38509571 Free PMC article. - A comprehensive review of oral microenvironment changes and orofacial adverse reactions after COVID-19 vaccination: The good, the bad, and the ugly.
Najary S, Vatankhah M, Khadivi G, Salehi SN, Tabari MAK, Samieefar N, Behnaz M. Najary S, et al. Health Sci Rep. 2024 Mar 13;7(3):e1967. doi: 10.1002/hsr2.1967. eCollection 2024 Mar. Health Sci Rep. 2024. PMID: 38482134 Free PMC article. - Alterations in intestinal Archaea composition in pediatric patients with Crohn's disease based on next-generation sequencing - a pilot study.
Krawczyk A, Gosiewski T, Zapała B, Kowalska-Duplaga K, Salamon D. Krawczyk A, et al. Gut Microbes. 2023 Dec;15(2):2276806. doi: 10.1080/19490976.2023.2276806. Epub 2023 Nov 13. Gut Microbes. 2023. PMID: 37955638 Free PMC article. - Molecular mimicry and cancer vaccine development.
Tagliamonte M, Cavalluzzo B, Mauriello A, Ragone C, Buonaguro FM, Tornesello ML, Buonaguro L. Tagliamonte M, et al. Mol Cancer. 2023 Apr 26;22(1):75. doi: 10.1186/s12943-023-01776-0. Mol Cancer. 2023. PMID: 37101139 Free PMC article. Review. - A Rare Case of COVID-19 Associated With Autoimmune Hemolytic Anemia, Thrombocytopenia and Acute Kidney Injury.
Musa M, Abdalla EM, Elhaj MF, Mustafa S, Ahmed SA, Sajid J. Musa M, et al. Cureus. 2022 Jun 16;14(6):e26010. doi: 10.7759/cureus.26010. eCollection 2022 Jun. Cureus. 2022. PMID: 35859968 Free PMC article.
References
- Bach J-F. Predictive medicine in autoimmune diseases: from the identification of genetic predisposition and environmental influence to precocious immunotherapy. Clin Immunol Immunopath. 1994;72:156–161. - PubMed
- Theophilopoulos A. The basis of autoimmunity: part II, genetic predisposition. Immunol Today. 1995;16:150–159. - PubMed
- Tisch R, McDevitt H. Insulin-dependent diabetes mellitus. Cell. 1996;85:291–297. - PubMed
- Ebers G, Bulman D, Sadovnik A, Paty D, Warren S, Hader W, Murray T, Seland T, Duquette P, Grey T. A population based study of multiple sclerosis in twins. N Engl J Med. 1987;315:1638–1642. - PubMed
- Miller S, Karpus WJ. The immune pathogenesis and regulation of T-cell mediated demyelinating diseases. Immunol Today. 1994;15:358–362. - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials