Regulation of STAT-dependent pathways by growth factors and cytokines - PubMed (original) (raw)
Review
. 1996 Dec;10(14):1578-88.
Affiliations
- PMID: 9002549
Review
Regulation of STAT-dependent pathways by growth factors and cytokines
D W Leaman et al. FASEB J. 1996 Dec.
Abstract
Polypeptide growth factors and cytokines elicit their effects by activating specific cell-surface receptors, thereby initiating signaling cascades that culminate in the induction of specific subsets of genes. Initially identified as the primary mediators of interferon-dependent signaling, JAKs and STATs are now known to be utilized by many different extracellular signaling proteins. In this report we describe how JAK-STAT pathways transduce signals initiated by both cytokines and growth factors, focusing on how specificity is achieved through STAT-receptor interactions and on how receptor-associated kinases function in STAT activation. We also summarize current information on interactions between signaling pathways, particularly STAT-Ras cross-talk and the relative importance of these two pathways in regulating the transcription of target genes.
Similar articles
- The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus.
Heim MH. Heim MH. J Recept Signal Transduct Res. 1999 Jan-Jul;19(1-4):75-120. doi: 10.3109/10799899909036638. J Recept Signal Transduct Res. 1999. PMID: 10071751 Review. - Cytokines and JAK-STAT signaling.
Schindler C. Schindler C. Exp Cell Res. 1999 Nov 25;253(1):7-14. doi: 10.1006/excr.1999.4670. Exp Cell Res. 1999. PMID: 10579906 Review. - Jak-STAT signaling pathways in cells of the immune system.
Ivashkiv LB. Ivashkiv LB. Rev Immunogenet. 2000;2(2):220-30. Rev Immunogenet. 2000. PMID: 11258419 Review. - STATs as critical mediators of signal transduction and transcription: lessons learned from STAT5.
Paukku K, Silvennoinen O. Paukku K, et al. Cytokine Growth Factor Rev. 2004 Dec;15(6):435-55. doi: 10.1016/j.cytogfr.2004.09.001. Cytokine Growth Factor Rev. 2004. PMID: 15561601 Review. - The role of STATs in transcriptional control and their impact on cellular function.
Bromberg J, Darnell JE Jr. Bromberg J, et al. Oncogene. 2000 May 15;19(21):2468-73. doi: 10.1038/sj.onc.1203476. Oncogene. 2000. PMID: 10851045 Review.
Cited by
- Salicylate-enhanced activation of transcription factors induced by interferon-gamma.
Chen LC, Kepka-Lenhart D, Wright TM, Morris SM Jr. Chen LC, et al. Biochem J. 1999 Sep 15;342 Pt 3(Pt 3):503-7. Biochem J. 1999. PMID: 10477259 Free PMC article. - LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1.
Weiskirchen R, Moser M, Weiskirchen S, Erdel M, Dahmen S, Buettner R, Gressner AM. Weiskirchen R, et al. Biochem J. 2001 Nov 1;359(Pt 3):485-96. doi: 10.1042/0264-6021:3590485. Biochem J. 2001. PMID: 11672422 Free PMC article. - STAT3 regulates inflammatory cytokine production downstream of TNFR1 by inducing expression of TNFAIP3/A20.
Antonia RJ, Karelehto E, Toriguchi K, Matli M, Warren RS, Pfeffer LM, Donner DB. Antonia RJ, et al. J Cell Mol Med. 2022 Aug;26(16):4591-4601. doi: 10.1111/jcmm.17489. Epub 2022 Jul 16. J Cell Mol Med. 2022. PMID: 35841281 Free PMC article. - Lipopolysaccharide-induced failure of the gut barrier is site-specific and inhibitable by growth hormone.
Yue C, Wang W, Tian WL, Huang Q, Zhao RS, Zhao YZ, Li QR, Li JS. Yue C, et al. Inflamm Res. 2013 Apr;62(4):407-15. doi: 10.1007/s00011-013-0593-4. Epub 2013 Jan 23. Inflamm Res. 2013. PMID: 23340865
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Research Materials
Miscellaneous