[Clinical experience with the use of ofloxacin in infections of the upper and lower urinary tracts: demonstrations of the results of clinical trials] - PubMed (original) (raw)

[Article in Russian]

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Clinical Trial

[Clinical experience with the use of ofloxacin in infections of the upper and lower urinary tracts: demonstrations of the results of clinical trials]

[Article in Russian]

G Liudvig. Antibiot Khimioter. 1996.

Abstract

The efficacy and safety of ofloxacin in the treatment of upper and lower urinary tract infections were studied with the drug use according to 4 regimens by comparison with nitrofurantoin in the treatment of lower urinary tract infections and trimethoprim/sulfamethoxazole in the treatment of upper urinary tract infections. Ofloxacin was used in doses of 100 to 200 mg once or twice a day for 3, 5 and 10 days. In a separate group of 30 female patients with frequent recurring noncomplicated lower urinary tract infections ofloxacin was used in a dose of 50 mg once a day for 6 months. Ofloxacin was shown to be highly efficient in the treatment of medium and severe infections of the upper and lower urinary tracts. The following regimens were recommended: 200 mg once a day in the treatment of medium urinary tract infections, 100 mg twice a day for 3 to 7 days in the treatment of severe infections of the lower urinary tract and 200 mg twice a day for 7 to 10 days in the treatment of severe upper urinary tract infections. The use of ofloxacin in a daily dose of 50 mg for 6 months proved to be efficient in the treatment of frequent acute recurring infections of the urinary tracts.

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