Integrin-mediated calcium signaling and regulation of cell adhesion by intracellular calcium - PubMed (original) (raw)
Review
Integrin-mediated calcium signaling and regulation of cell adhesion by intracellular calcium
M D Sjaastad et al. Bioessays. 1997 Jan.
Abstract
Integrins are ubiquitous trans-membrane adhesion molecules that mediate the interaction of cells with the extracellular matrix (ECM). Integrins link cells to the ECM by interacting with the cell cytoskeleton. In cases such as leukocyte binding, integrins mediate cell-cell interactions and cell-ECM interactions. Recent research indicates that integrins also function as signal transduction receptors, triggering a number of intracellular signaling pathways that regulate cell behavior and development. A number of integrins are known to stimulate changes in intracellular calcium levels, resulting in integrin activation. Although changes in intracellular calcium regulate a vast number of cellular functions, this review will discuss the stimulation of calcium signaling by integrins and the role of intracellular calcium in the regulation of integrin-mediated adhesion.
Similar articles
- Regulation of integrin-mediated adhesion during cell migration.
Cox EA, Huttenlocher A. Cox EA, et al. Microsc Res Tech. 1998 Dec 1;43(5):412-9. doi: 10.1002/(SICI)1097-0029(19981201)43:5<412::AID-JEMT7>3.0.CO;2-F. Microsc Res Tech. 1998. PMID: 9858338 Review. - Assembly and signaling of adhesion complexes.
Sepulveda JL, Gkretsi V, Wu C. Sepulveda JL, et al. Curr Top Dev Biol. 2005;68:183-225. doi: 10.1016/S0070-2153(05)68007-6. Curr Top Dev Biol. 2005. PMID: 16125000 Review. - A role for beta2 integrin (CD11/CD18)-mediated tyrosine signaling in extravasation of human polymorphonuclear neutrophils.
Willeke T, Scharffetter-Kochanek K, Gaehtgens P, Walzog B. Willeke T, et al. Biorheology. 2001;38(2-3):89-100. Biorheology. 2001. PMID: 11381167 - Regulation of integrin function and cellular adhesion.
Stuiver I, O'Toole TE. Stuiver I, et al. Stem Cells. 1995 May;13(3):250-62. doi: 10.1002/stem.5530130306. Stem Cells. 1995. PMID: 7613492 Review. - Integrin signaling in malignant melanoma.
Kuphal S, Bauer R, Bosserhoff AK. Kuphal S, et al. Cancer Metastasis Rev. 2005 Jun;24(2):195-222. doi: 10.1007/s10555-005-1572-1. Cancer Metastasis Rev. 2005. PMID: 15986132 Review.
Cited by
- Cold Atmospheric Pressure Plasma-Activated Medium Modulates Cellular Functions of Human Mesenchymal Stem/Stromal Cells In Vitro.
Hahn O, Waheed TO, Sridharan K, Huemerlehner T, Staehlke S, Thürling M, Boeckmann L, Meister M, Masur K, Peters K. Hahn O, et al. Int J Mol Sci. 2024 May 1;25(9):4944. doi: 10.3390/ijms25094944. Int J Mol Sci. 2024. PMID: 38732164 Free PMC article. - Human dental pulp stem cells derived extracellular matrix promotes mineralization via Hippo and Wnt pathways.
Kornsuthisopon C, Nowwarote N, Chansaenroj A, Photichailert S, Rochanavibhata S, Klincumhom N, Petit S, Dingli F, Loew D, Fournier BPJ, Osathanon T. Kornsuthisopon C, et al. Sci Rep. 2024 Mar 21;14(1):6777. doi: 10.1038/s41598-024-56845-1. Sci Rep. 2024. PMID: 38514682 Free PMC article. - Force-Regulated Calcium Signaling of Lymphoid Cell RPMI 8226 Mediated by Integrin α4β7/MAdCAM-1 in Flow.
Sun D, Luo Z, Kong Y, Huang R, Li Q. Sun D, et al. Biomolecules. 2023 Mar 24;13(4):587. doi: 10.3390/biom13040587. Biomolecules. 2023. PMID: 37189336 Free PMC article. - Knockdown of the salivary protein gene NlG14 caused displacement of the lateral oviduct secreted components and inhibited ovulation in Nilaparvata lugens.
Gao H, Zhang H, Yuan X, Lin X, Zou J, Yu N, Liu Z. Gao H, et al. PLoS Genet. 2023 Apr 3;19(4):e1010704. doi: 10.1371/journal.pgen.1010704. eCollection 2023 Apr. PLoS Genet. 2023. PMID: 37011098 Free PMC article. - Pulsed Electrical Stimulation Affects Osteoblast Adhesion and Calcium Ion Signaling.
Staehlke S, Bielfeldt M, Zimmermann J, Gruening M, Barke I, Freitag T, Speller S, Van Rienen U, Nebe B. Staehlke S, et al. Cells. 2022 Aug 25;11(17):2650. doi: 10.3390/cells11172650. Cells. 2022. PMID: 36078058 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources