Development of a murine model of chronic Salmonella infection - PubMed (original) (raw)

Development of a murine model of chronic Salmonella infection

S Sukupolvi et al. Infect Immun. 1997 Feb.

Abstract

The invasive disease caused by Salmonella typhimurium in mice resembles the acute phase of human typhoid fever caused by Salmonella typhi, and experimental murine salmonellosis is a widely used experimental model for systemic salmonellosis. In this paper we demonstrate that murine S. typhimurium infection can also be used to model the development of the chronic carrier state that develops in humans after infection with S. typhi. We describe a virulent variant of S. typhimurium that has decreased expression of AgfA fibers under all environmental conditions studied and that causes a chronic carrier state in BALB/c mice after peroral inoculation. The chronic carrier state is associated with persistence of bacteria in the small intestine, spleen, and liver, and chronic infection continues despite the development of protective immunity to challenge with virulent Salmonella.

PubMed Disclaimer

Similar articles

• Role of sigma factor RpoS in initial stages of Salmonella typhimurium infection.
  Nickerson CA, Curtiss R 3rd. Nickerson CA, et al. Infect Immun. 1997 May;65(5):1814-23. doi: 10.1128/iai.65.5.1814-1823.1997. Infect Immun. 1997. PMID: 9125566 Free PMC article.
• Virulence and vaccine potential of Salmonella typhimurium mutants deficient in the expression of the RpoS (sigma S) regulon.
  Coynault C, Robbe-Saule V, Norel F. Coynault C, et al. Mol Microbiol. 1996 Oct;22(1):149-60. doi: 10.1111/j.1365-2958.1996.tb02664.x. Mol Microbiol. 1996. PMID: 8899717
• Dual role for macrophages in vivo in pathogenesis and control of murine Salmonella enterica var. Typhimurium infections.
  Wijburg OL, Simmons CP, van Rooijen N, Strugnell RA. Wijburg OL, et al. Eur J Immunol. 2000 Mar;30(3):944-53. doi: 10.1002/1521-4141(200003)30:3<944::AID-IMMU944>3.0.CO;2-1. Eur J Immunol. 2000. PMID: 10741413
• The intracellular nature of Salmonella infection during the early stages of mouse typhoid.
  Dunlap NE, Benjamin WH Jr, Briles DE. Dunlap NE, et al. Immunol Ser. 1994;60:303-12. Immunol Ser. 1994. PMID: 8251577 Review.
• Tracking the dynamics of salmonella specific T cell responses.
  Moon JJ, McSorley SJ. Moon JJ, et al. Curr Top Microbiol Immunol. 2009;334:179-98. doi: 10.1007/978-3-540-93864-4_8. Curr Top Microbiol Immunol. 2009. PMID: 19521686 Free PMC article. Review.

Cited by

• Salmonella typhimurium virulence genes are induced upon bacterial invasion into phagocytic and nonphagocytic cells.
  Pfeifer CG, Marcus SL, Steele-Mortimer O, Knodler LA, Finlay BB. Pfeifer CG, et al. Infect Immun. 1999 Nov;67(11):5690-8. doi: 10.1128/IAI.67.11.5690-5698.1999. Infect Immun. 1999. PMID: 10531217 Free PMC article.
• Disruption of the genes for ClpXP protease in Salmonella enterica serovar Typhimurium results in persistent infection in mice, and development of persistence requires endogenous gamma interferon and tumor necrosis factor alpha.
  Yamamoto T, Sashinami H, Takaya A, Tomoyasu T, Matsui H, Kikuchi Y, Hanawa T, Kamiya S, Nakane A. Yamamoto T, et al. Infect Immun. 2001 May;69(5):3164-74. doi: 10.1128/IAI.69.5.3164-3174.2001. Infect Immun. 2001. PMID: 11292737 Free PMC article.
• Lon, a stress-induced ATP-dependent protease, is critically important for systemic Salmonella enterica serovar typhimurium infection of mice.
  Takaya A, Suzuki M, Matsui H, Tomoyasu T, Sashinami H, Nakane A, Yamamoto T. Takaya A, et al. Infect Immun. 2003 Feb;71(2):690-6. doi: 10.1128/IAI.71.2.690-696.2003. Infect Immun. 2003. PMID: 12540547 Free PMC article.
• Chronic Salmonella infected mouse model.
  Wu S, Lu R, Zhang YG, Sun J. Wu S, et al. J Vis Exp. 2010 May 31;(39):1947. doi: 10.3791/1947. J Vis Exp. 2010. PMID: 20526278 Free PMC article.
• Salmonella enterica serovar typhimurium induces cell death in bovine monocyte-derived macrophages by early sipB-dependent and delayed sipB-independent mechanisms.
  Santos RL, Tsolis RM, Bäumler AJ, Smith R 3rd, Adams LG. Santos RL, et al. Infect Immun. 2001 Apr;69(4):2293-301. doi: 10.1128/IAI.69.4.2293-2301.2001. Infect Immun. 2001. PMID: 11254586 Free PMC article.

References

1. 1. J Bacteriol. 1993 Jan;175(1):12-8 - PubMed
2. 1. Nature. 1989 Apr 20;338(6217):652-5 - PubMed
3. 1. Infect Immun. 1988 Feb;56(2):419-23 - PubMed
4. 1. Mol Microbiol. 1993 Feb;7(4):523-36 - PubMed
5. 1. Infect Immun. 1985 Sep;49(3):523-7 - PubMed

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Europe PubMed Central
  • PubMed Central

• Molecular Biology Databases

  • Mouse Genome Informatics (MGI)