Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs - PubMed (original) (raw)
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Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs
J E Ferrell Jr. Trends Biochem Sci. 1996 Dec.
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Abstract
Recent experimental work has shown that the mitogen-activated protein (MAP) kinase cascade can convert graded inputs into switch-like outputs. The cascade could therefore filter out noise (signals of insufficient magnitude or duration) and still respond decisively to supra-threshold stimuli. Here, we explore the biochemical mechanisms likely to be at the root of this behavior.
Comment in
- Why do protein kinase cascades have more than one level?
Brown GC, Hoek JB, Kholodenko BN. Brown GC, et al. Trends Biochem Sci. 1997 Aug;22(8):288. doi: 10.1016/s0968-0004(97)82216-5. Trends Biochem Sci. 1997. PMID: 9270298 No abstract available.
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