Cytokine expression in the gut associated lymphoid tissue after oral administration of attenuated Salmonella vaccine strains - PubMed (original) (raw)
Cytokine expression in the gut associated lymphoid tissue after oral administration of attenuated Salmonella vaccine strains
K L Karem et al. Vaccine. 1996 Nov.
Abstract
The use of attenuated Salmonella vaccine vectors as delivery vehicles for heterologous antigens has been extensive. The majority of work has analyzed the specific immune responses to the recombinant antigen in question. In addition, most analysis has been performed on animals maintained with sterile food, water, and bedding. This report defines the Salmonella specific cytokine responses in the gut associated lymphoid tissue after oral immunization with two highly publicized attenuated Salmonella carrier strains in animals maintained with nonsterile food, water, and bedding. Increases in expression of both IL-4 and IFN-gamma occur following immunization with either Salmonella construct. In addition, other cytokines (IL-6, IL-7, IL-12) increase at similar levels in either BRD509 or KR1 dosed animals. Proinflammatory cytokines IL-1 and TNF-alpha are also present but unchanged at early time points (6, 24, and 72 hours), increasing only after 7 days postimmunization. These data have implications in the generation of immunity to recombinant antigens since the response to Salmonella will dictate the direction of responses in terms of CD4 T cell activation.
Similar articles
- Systemic and mucosal immunity induced by attenuated Salmonella enterica serovar Typhimurium expressing ORF7 of porcine reproductive and respiratory syndrome virus.
Han YW, Kim SB, Rahman M, Uyangaa E, Lee BM, Kim JH, Park KI, Hong JT, Han SB, Eo SK. Han YW, et al. Comp Immunol Microbiol Infect Dis. 2011 Jul;34(4):335-45. doi: 10.1016/j.cimid.2011.04.001. Epub 2011 May 2. Comp Immunol Microbiol Infect Dis. 2011. PMID: 21543119 - Salmonella enterica serovar Typhimurium strain lacking pmrG-HM-D provides excellent protection against salmonellosis in murine typhoid model.
Negi VD, Singhamahapatra S, Chakravortty D. Negi VD, et al. Vaccine. 2007 Jul 20;25(29):5315-23. doi: 10.1016/j.vaccine.2007.05.015. Epub 2007 Jun 4. Vaccine. 2007. PMID: 17574312 - Interferon gamma (IFN-gamma) production by gut-associated lymphoid tissue and spleen following oral Salmonella typhimurium challenge.
Ramarathinam L, Shaban RA, Niesel DW, Klimpel GR. Ramarathinam L, et al. Microb Pathog. 1991 Nov;11(5):347-56. doi: 10.1016/0882-4010(91)90020-b. Microb Pathog. 1991. PMID: 1816488 - Differential cytokine mRNA expression in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): dose response and time course.
Zhou HR, Yan D, Pestka JJ. Zhou HR, et al. Toxicol Appl Pharmacol. 1997 Jun;144(2):294-305. doi: 10.1006/taap.1997.8132. Toxicol Appl Pharmacol. 1997. PMID: 9194413 - The use of live attenuated Salmonella for oral vaccination.
Chatfield S, Roberts M, Li J, Starns A, Dougan G. Chatfield S, et al. Dev Biol Stand. 1994;82:35-42. Dev Biol Stand. 1994. PMID: 7958481 Review.
Cited by
- Salmonella enterica serovar Typhimurium lacking hfq gene confers protective immunity against murine typhoid.
Allam US, Krishna MG, Lahiri A, Joy O, Chakravortty D. Allam US, et al. PLoS One. 2011 Feb 9;6(2):e16667. doi: 10.1371/journal.pone.0016667. PLoS One. 2011. PMID: 21347426 Free PMC article. - Study of the role of the htrB gene in Salmonella typhimurium virulence.
Jones BD, Nichols WA, Gibson BW, Sunshine MG, Apicella MA. Jones BD, et al. Infect Immun. 1997 Nov;65(11):4778-83. doi: 10.1128/iai.65.11.4778-4783.1997. Infect Immun. 1997. PMID: 9353064 Free PMC article. - Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells.
Iwasaki A, Kelsall BL. Iwasaki A, et al. J Exp Med. 1999 Jul 19;190(2):229-39. doi: 10.1084/jem.190.2.229. J Exp Med. 1999. PMID: 10432286 Free PMC article. - Murine Peyer's patch dendritic cells prime naïve CD4(+) T cells to produce interferon-gamma.
Sato A, Hashiguchi M, Hachimura S, Kaminogawa S. Sato A, et al. Cytotechnology. 2002 Nov;40(1-3):31-8. doi: 10.1023/A:1023949620172. Cytotechnology. 2002. PMID: 19003102 Free PMC article. - Flagellin from recombinant attenuated Salmonella enterica serovar Typhimurium reveals a fundamental role in chicken innate immunity.
Pan Z, Cong Q, Geng S, Fang Q, Kang X, You M, Jiao X. Pan Z, et al. Clin Vaccine Immunol. 2012 Mar;19(3):304-12. doi: 10.1128/CVI.05569-11. Epub 2012 Jan 11. Clin Vaccine Immunol. 2012. PMID: 22237893 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials