Defective transcription-coupled repair of oxidative base damage in Cockayne syndrome patients from XP group G - PubMed (original) (raw)
Defective transcription-coupled repair of oxidative base damage in Cockayne syndrome patients from XP group G
P K Cooper et al. Science. 1997.
Retraction in
- Retraction.
Cooper PK, Nouspikel T, Clarkson SG. Cooper PK, et al. Science. 2005 Jun 17;308(5729):1740. doi: 10.1126/science.308.5729.1740b. Science. 2005. PMID: 15961651 No abstract available.
Abstract
In normal human cells, damage due to ultraviolet light is preferentially removed from active genes by nucleotide excision repair (NER) in a transcription-coupled repair (TCR) process that requires the gene products defective in Cockayne syndrome (CS). Oxidative damage, including thymine glycols, is shown to be removed by TCR in cells from normal individuals and from xeroderma pigmentosum (XP)-A, XP-F, and XP-G patients who have NER defects but not from XP-G patients who have severe CS. Thus, TCR of oxidative damage requires an XPG function distinct from its NER endonuclease activity. These results raise the possibility that defective TCR of oxidative damage contributes to the developmental defects associated with CS.
Comment in
- Findings of scientific misconduct.
[No authors listed] [No authors listed] NIH Guide Grants Contracts. 2006 Jun 9:NOT-OD-06-075. NIH Guide Grants Contracts. 2006. PMID: 16764107 Free PMC article. No abstract available.
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