Correlation between anti-Proteus antibodies and isolation rates of P. mirabilis in rheumatoid arthritis - PubMed (original) (raw)

Comparative Study

doi: 10.1007/BF01330294.

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Comparative Study

Correlation between anti-Proteus antibodies and isolation rates of P. mirabilis in rheumatoid arthritis

C Wilson et al. Rheumatol Int. 1997.

Abstract

In a survey of 89 RA patients, carried out under code, Proteus mirabilis was isolated from the urine of 63% (47/75) of female (P < 0.001) and 50% (7/14) of male patients (P < 0.001), compared to a frequency of isolation in healthy women of 32% (38/119) and 11% (13/115) in healthy men. There was no significant difference in isolation rates between 37 non-RA patients and healthy controls. Sera from 20 patients with RA and 20 healthy controls were tested against P. mirabilis and Escherichia coli by an enzyme-linked immunosorbent assay. Antibodies against P. mirabilis but not to E. coli were significantly higher in the RA patients than in healthy controls (P < 0.001). Furthermore, a positive correlation was found between high anti-Proteus antibody levels in serum samples and the number of Proteus colony-forming units obtained from urine specimens of the 20 RA patients (r = +0.714, P < 0.001). These results support the suggestion of an aetiopathogenic role for P. mirabilis in RA.

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References

    1. Br J Rheumatol. 1988;27 Suppl 2:86-9 -PubMed
    1. Lancet. 1985 Aug 10;2(8450):305-7 -PubMed
    1. Lancet. 1971 Sep 18;2(7725):615-8 -PubMed
    1. Ann Rheum Dis. 1995 Mar;54(3):216-20 -PubMed
    1. Br J Rheumatol. 1994 Jan;33(1):32-5 -PubMed

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