The effects of anticonvulsant drugs on NMDA-EPSP, AMPA-EPSP, and GABA-IPSP in the rat hippocampus - PubMed (original) (raw)
The effects of anticonvulsant drugs on NMDA-EPSP, AMPA-EPSP, and GABA-IPSP in the rat hippocampus
G Y Ko et al. Brain Res Bull. 1997.
Abstract
The effects of phenobarbital, phenytoin, and valproic acid on pharmacologically isolated NMDA-EPSP, AMPA-EPSP, and GABA-IPSPs were examined in rat hippocampal slices. Phenobarbital (0.05 mg/ml) had no effect on the NMDA-EPSP, but decreased the slope of the AMPA-EPSP by 13.4% and facilitated the GABA-IPSP slope by 77.12%. Phenytoin (0.02 mg/ml) had no effects on the NMDA-EPSP, AMPA-EPSP, or GABA-IPSP. Valproic acid (0.1 mg/ml) decreased the NMDA-EPSP slope by 14.3%, increased the GABA-IPSP slope by 54.34%, and had no effect on the AMPA-EPSP. These data suggest that the mechanisms of action of these anticonvulsant drugs may be via their actions on different neurotransmitter systems or ion channels.
Similar articles
- Muscarinic reduction of GABAergic synaptic potentials results in disinhibition of the AMPA/kainate-mediated EPSP in auditory cortex.
Aramakis VB, Bandrowski AE, Ashe JH. Aramakis VB, et al. Brain Res. 1997 May 30;758(1-2):107-17. doi: 10.1016/s0006-8993(97)00205-9. Brain Res. 1997. PMID: 9203539 - NMDA-Independent LTP by adenosine A2 receptor-mediated postsynaptic AMPA potentiation in hippocampus.
Kessey K, Mogul DJ. Kessey K, et al. J Neurophysiol. 1997 Oct;78(4):1965-72. doi: 10.1152/jn.1997.78.4.1965. J Neurophysiol. 1997. PMID: 9325364 - Activation of non-NMDA receptors stimulates acetylcholine and GABA release from dorsal hippocampus: a microdialysis study in the rat.
Giovannini MG, Rakovska A, Della Corte L, Bianchi L, Pepeu G. Giovannini MG, et al. Neurosci Lett. 1998 Feb 27;243(1-3):152-6. doi: 10.1016/s0304-3940(98)00091-3. Neurosci Lett. 1998. PMID: 9535136 - [Long-term potentiation of the NMDA-dependent component of the EPSP in the hippocampus].
Kleshchevnikov AM. Kleshchevnikov AM. Usp Fiziol Nauk. 1998 Oct-Dec;29(4):6-23. Usp Fiziol Nauk. 1998. PMID: 9883495 Review. Russian. - Effects of the antiepileptic drug valproate on metabolism and function of inhibitory and excitatory amino acids in the brain.
Löscher W. Löscher W. Neurochem Res. 1993 Apr;18(4):485-502. doi: 10.1007/BF00967253. Neurochem Res. 1993. PMID: 8097295 Review.
Cited by
- Exploring the Therapeutic Potential of N-Methyl-D-Aspartate Receptor Antagonists in Neuropathic Pain Management.
Pușcașu C, Chiriță C, Negreș S, Blebea NM. Pușcașu C, et al. Int J Mol Sci. 2024 Oct 16;25(20):11111. doi: 10.3390/ijms252011111. Int J Mol Sci. 2024. PMID: 39456894 Free PMC article. Review. - Excitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus.
Burman RJ, Selfe JS, Lee JH, van den Berg M, Calin A, Codadu NK, Wright R, Newey SE, Parrish RR, Katz AA, Wilmshurst JM, Akerman CJ, Trevelyan AJ, Raimondo JV. Burman RJ, et al. Brain. 2019 Nov 1;142(11):3482-3501. doi: 10.1093/brain/awz283. Brain. 2019. PMID: 31553050 Free PMC article. - Excitatory and inhibitory synaptic dysfunction in mania: an emerging hypothesis from animal model studies.
Lee Y, Zhang Y, Kim S, Han K. Lee Y, et al. Exp Mol Med. 2018 Apr 9;50(4):1-11. doi: 10.1038/s12276-018-0028-y. Exp Mol Med. 2018. PMID: 29628501 Free PMC article. Review. - Deep brain stimulation, histone deacetylase inhibitors and glutamatergic drugs rescue resistance to fear extinction in a genetic mouse model.
Whittle N, Schmuckermair C, Gunduz Cinar O, Hauschild M, Ferraguti F, Holmes A, Singewald N. Whittle N, et al. Neuropharmacology. 2013 Jan;64(4):414-23. doi: 10.1016/j.neuropharm.2012.06.001. Epub 2012 Jun 18. Neuropharmacology. 2013. PMID: 22722028 Free PMC article. - Proof of concept trials in bipolar disorder and major depressive disorder: a translational perspective in the search for improved treatments.
Machado-Vieira R, Zarate CA Jr. Machado-Vieira R, et al. Depress Anxiety. 2011 Apr;28(4):267-81. doi: 10.1002/da.20800. Epub 2011 Feb 24. Depress Anxiety. 2011. PMID: 21456037 Free PMC article. Review.