Both E12 and E47 allow commitment to the B cell lineage - PubMed (original) (raw)
Both E12 and E47 allow commitment to the B cell lineage
G Bain et al. Immunity. 1997 Feb.
Free article
Abstract
The E2A gene products, E12 and E47, are required for proper B cell development. Mice lacking the E2A gene products generate only a very small number of B220+ cells, which lack immunoglobulin DJ(H) rearrangements. We have now generated mice expressing either E12 or E47. B cell development in mice expressing E12 but lacking E47 is perturbed at the pro-B cell stage, and these mice lack IgM+B220+ B cells in both bone marrow and spleen. IgM+B220+ B cells can be detected, albeit at significantly reduced levels, in the bone marrow and spleen of mice lacking E12. Ectopic expression of both E12 and E47 in a null mutant background shows that E12 and E47 act in concert to promote B lineage development. Taken together, the data indicate that both E12 and E47 allow commitment to the B cell lineage and act synergistically to promote B lymphocyte maturation.
Similar articles
- Decreased E12 and/or E47 transcription factor activity in the bone marrow as well as in the spleen of aged mice.
Frasca D, Nguyen D, Riley RL, Blomberg BB. Frasca D, et al. J Immunol. 2003 Jan 15;170(2):719-26. doi: 10.4049/jimmunol.170.2.719. J Immunol. 2003. PMID: 12517933 - Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci.
Beck K, Peak MM, Ota T, Nemazee D, Murre C. Beck K, et al. J Exp Med. 2009 Sep 28;206(10):2271-84. doi: 10.1084/jem.20090756. Epub 2009 Sep 14. J Exp Med. 2009. PMID: 19752184 Free PMC article. - E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements.
Bain G, Maandag EC, Izon DJ, Amsen D, Kruisbeek AM, Weintraub BC, Krop I, Schlissel MS, Feeney AJ, van Roon M, et al. Bain G, et al. Cell. 1994 Dec 2;79(5):885-92. doi: 10.1016/0092-8674(94)90077-9. Cell. 1994. PMID: 8001125 - E protein function in lymphocyte development.
Quong MW, Romanow WJ, Murre C. Quong MW, et al. Annu Rev Immunol. 2002;20:301-22. doi: 10.1146/annurev.immunol.20.092501.162048. Epub 2001 Oct 4. Annu Rev Immunol. 2002. PMID: 11861605 Review. - Fidelity and infidelity in commitment to B-lymphocyte lineage development.
Rolink AG, Schaniel C, Busslinger M, Nutt SL, Melchers F. Rolink AG, et al. Immunol Rev. 2000 Jun;175:104-11. Immunol Rev. 2000. PMID: 10933595 Review.
Cited by
- The Function of E2A in B-Cell Development.
Miyazaki M, Miyazaki K. Miyazaki M, et al. Adv Exp Med Biol. 2024;1459:97-113. doi: 10.1007/978-3-031-62731-6_5. Adv Exp Med Biol. 2024. PMID: 39017841 Review. - The advances of E2A-PBX1 fusion in B-cell acute lymphoblastic Leukaemia.
Yang M, Tang Y, Zhu P, Lu H, Wan X, Guo Q, Xiao L, Liu C, Guo L, Liu W, Yang Y. Yang M, et al. Ann Hematol. 2024 Sep;103(9):3385-3398. doi: 10.1007/s00277-023-05595-7. Epub 2023 Dec 27. Ann Hematol. 2024. PMID: 38148344 Review. - E47 as a novel glucocorticoid-dependent gene mediating lipid metabolism in patients with endogenous glucocorticoid excess.
Zhang W, Nowotny H, Theodoropoulou M, Simon J, Hemmer CM, Bidlingmaier M, Auer MK, Reincke M, Uhlenhaut H, Reisch N. Zhang W, et al. Front Endocrinol (Lausanne). 2023 Nov 17;14:1249863. doi: 10.3389/fendo.2023.1249863. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 38047107 Free PMC article. - TCF3 haploinsufficiency defined by immune, clinical, gene-dosage, and murine studies.
Boast B, Goel S, González-Granado LI, Niemela J, Stoddard J, Edwards ESJ, Seneviratne S, Spensberger D, Quesada-Espinosa JF, Allende LM, McDonnell J, Haseley A, Lesmana H, Walkiewicz MA, Muhammad E, Bosco JJ, Fleisher TA, Cohen S, Holland SM, van Zelm MC, Enders A, Kuehn HS, Rosenzweig SD. Boast B, et al. J Allergy Clin Immunol. 2023 Sep;152(3):736-747. doi: 10.1016/j.jaci.2023.05.017. Epub 2023 Jun 3. J Allergy Clin Immunol. 2023. PMID: 37277074 Free PMC article. - A p38α-BLIMP1 signalling pathway is essential for plasma cell differentiation.
Wu J, Yang K, Cai S, Zhang X, Hu L, Lin F, Wu SQ, Xiao C, Liu WH, Han J. Wu J, et al. Nat Commun. 2022 Nov 28;13(1):7321. doi: 10.1038/s41467-022-34969-0. Nat Commun. 2022. PMID: 36443297 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials