An endothelial receptor for oxidized low-density lipoprotein - PubMed (original) (raw)

. 1997 Mar 6;386(6620):73-7.

doi: 10.1038/386073a0.

Affiliations

• PMID: 9052782
• DOI: 10.1038/386073a0

An endothelial receptor for oxidized low-density lipoprotein

T Sawamura et al. Nature. 1997.

Abstract

Endothelial dysfunction or activation elicited by oxidatively modified low-density lipoprotein (Ox-LDL) has been implicated in the pathogenesis of atherosclerosis, characterized by intimal thickening and lipid deposition in the arteries. Ox-LDL and its lipid constituents impair endothelial production of nitric oxide, and induce the endothelial expression of leukocyte adhesion molecules and smooth-muscle growth factors, which may be involved in atherogenesis. Vascular endothelial cells in culture and in vivo internalize and degrade Ox-LDL through a putative receptor-mediated pathway that does not involve macrophage scavenger receptors. Here we report the molecular cloning, using expression cloning strategy, of an Ox-LDL receptor from vascular endothelial cells. The cloned receptor is a membrane protein that belongs structurally to the C-type lectin family, and is expressed in vivo in vascular endothelium and vascular-rich organs.

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