Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation - PubMed (original) (raw)
Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation
G Sauvageau et al. Immunity. 1997 Jan.
Free article
Abstract
HOXB3 mRNA levels are high in the earliest CD34+ lineage- bone marrow cells and low to undetectable in later CD34+/CD34- cells. To gain some insight into the role this gene may play in hematopoiesis, HOXB3 was overexpressed in murine bone marrow cells using retroviral gene transfer. Thymi of HOXB3 marrow recipients were reduced in size compared with control transplant recipients, with a 24-fold decrease in the absolute number of CD4+ CD8+ cells and a 3-fold increase in the number of CD4- CD8- thymocytes that contained a high proportion of gammadelta TCR+ cells. B cell differentiation was also perturbed in these mice, as indicated by the virtual absence of transduced IL-7-responsive pre-B clonogenic progenitors. Recipients of HOXB3-transduced cells also had elevated numbers of mature granulocyte macrophage colony-forming cells in their bone marrow and spleen. Together these results suggest roles for HOXB3 in proliferation and differentiation processes of both early myeloid and lymphoid developmental pathways.
Similar articles
- Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia.
Thorsteinsdottir U, Sauvageau G, Hough MR, Dragowska W, Lansdorp PM, Lawrence HJ, Largman C, Humphries RK. Thorsteinsdottir U, et al. Mol Cell Biol. 1997 Jan;17(1):495-505. doi: 10.1128/MCB.17.1.495. Mol Cell Biol. 1997. PMID: 8972230 Free PMC article. - Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo.
Sauvageau G, Thorsteinsdottir U, Eaves CJ, Lawrence HJ, Largman C, Lansdorp PM, Humphries RK. Sauvageau G, et al. Genes Dev. 1995 Jul 15;9(14):1753-65. doi: 10.1101/gad.9.14.1753. Genes Dev. 1995. PMID: 7622039 - Hoxb3 deficiency impairs B lymphopoiesis in mouse bone marrow.
Ko KH, Lam QL, Zhang M, Wong CK, Lo CK, Kahmeyer-Gabbe M, Tsang WH, Tsang SL, Chan LC, Sham MH, Lu L. Ko KH, et al. Exp Hematol. 2007 Mar;35(3):465-75. doi: 10.1016/j.exphem.2006.10.014. Exp Hematol. 2007. PMID: 17309827 - Fidelity and infidelity in commitment to B-lymphocyte lineage development.
Rolink AG, Schaniel C, Busslinger M, Nutt SL, Melchers F. Rolink AG, et al. Immunol Rev. 2000 Jun;175:104-11. Immunol Rev. 2000. PMID: 10933595 Review. - Biological and molecular evidence for existence of lymphoid-primed multipotent progenitors.
Luc S, Buza-Vidas N, Jacobsen SE. Luc S, et al. Ann N Y Acad Sci. 2007 Jun;1106:89-94. doi: 10.1196/annals.1392.023. Epub 2007 Apr 18. Ann N Y Acad Sci. 2007. PMID: 17442777 Review.
Cited by
- MicroRNA target homeobox messenger RNA in HIV induced hematopoietic inhibition.
Koka PS, Ramdass B. Koka PS, et al. Front Cell Dev Biol. 2024 Apr 24;12:1382789. doi: 10.3389/fcell.2024.1382789. eCollection 2024. Front Cell Dev Biol. 2024. PMID: 38721526 Free PMC article. - Identification of Cell Type-Specific Effects of DNMT3A Mutations on Relapse in Acute Myeloid Leukemia.
Bae SG, Kim HJ, Kim MY, Kim DDH, Shin SI, Ahn JS, Park J. Bae SG, et al. Mol Cells. 2023 Oct 31;46(10):611-626. doi: 10.14348/molcells.2023.0093. Epub 2023 Sep 27. Mol Cells. 2023. PMID: 37853686 Free PMC article. - Gene expression analysis in endometriosis: Immunopathology insights, transcription factors and therapeutic targets.
Geng R, Huang X, Li L, Guo X, Wang Q, Zheng Y, Guo X. Geng R, et al. Front Immunol. 2022 Nov 30;13:1037504. doi: 10.3389/fimmu.2022.1037504. eCollection 2022. Front Immunol. 2022. PMID: 36532015 Free PMC article. - Cerebrospinal fluid level of neurofilament light chain is associated with increased disease activity in neuro-Behçet's disease.
Karaaslan Z, Şanlı E, Timirci-Kahraman Ö, Yılmaz V, Akbayır E, Koral G, İçöz S, Gündüz T, Küçükali Cİ, Kürtünvü M, Tüzün E. Karaaslan Z, et al. Turk J Med Sci. 2022 Aug;52(4):1266-1273. doi: 10.55730/1300-0144.5432. Epub 2022 Aug 10. Turk J Med Sci. 2022. PMID: 36326394 Free PMC article. - Licochalcone A improves the cognitive ability of mice by regulating T- and B-cell proliferation.
Wu Y, Zhu J, Liu H, Liu H. Wu Y, et al. Aging (Albany NY). 2021 Mar 10;13(6):8895-8915. doi: 10.18632/aging.202704. Epub 2021 Mar 10. Aging (Albany NY). 2021. PMID: 33714945 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials