Quinine, intracellular pH and modulation of hemi-gap junctions in catfish horizontal cells - PubMed (original) (raw)
Quinine, intracellular pH and modulation of hemi-gap junctions in catfish horizontal cells
D B Dixon et al. Vision Res. 1996 Dec.
Free article
Abstract
Quinine increases the conductance of hemi-gap junctions in horizontal cells. We investigated the mechanisms of alkalinization and the hypothesis that quinine-induced alkalinization produced these conductance increases. We found that quinine-induced alkalinizations were not blocked by cobalt, amiloride, or DIDS. Therefore, this suggests that the alkalinization is not likely due to net proton flux through opened hemi-gap channels nor is it likely due to an action on Cl-/HCO3- exchanger or Na+/H+ exchanger, both of which are known to regulate pHi in the horizontal cells. Quinine increased hemi-gap conductance even when cells were recorded with patch pipets containing up to 80 mM HEPES. We conclude that quinine-induced alkalinization cannot account solely for the hemi-gap junctional conductance increases.
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