Rab3A small GTP-binding protein in Ca(2+)-dependent exocytosis - PubMed (original) (raw)
Review
Rab3A small GTP-binding protein in Ca(2+)-dependent exocytosis
Y Takai et al. Genes Cells. 1996 Jul.
Free article
Abstract
There exists a small GTP-binding protein (G protein) superfamily, consisting of more than 50 members, from yeast to mammal. The Rab family belongs to this superfamily and is implicated in intracellular vesicle trafficking. Rab3A small G protein is a member of the Rab3 subfamily which belongs to this Rab family. The regulators and downstream targets of Rab3A have been isolated, and evidence is accumulating that Rab3A and these Rab3A-interacting proteins are involved in Ca(2+)-dependent exocytosis, particularly in neurotransmitter release from nerve terminals.
Similar articles
- A novel rabconnectin-3-binding protein that directly binds a GDP/GTP exchange protein for Rab3A small G protein implicated in Ca(2+)-dependent exocytosis of neurotransmitter.
Kawabe H, Sakisaka T, Yasumi M, Shingai T, Izumi G, Nagano F, Deguchi-Tawarada M, Takeuchi M, Nakanishi H, Takai Y. Kawabe H, et al. Genes Cells. 2003 Jun;8(6):537-46. doi: 10.1046/j.1365-2443.2003.00655.x. Genes Cells. 2003. PMID: 12786944 - Rabphilin knock-out mice reveal that rabphilin is not required for rab3 function in regulating neurotransmitter release.
Schlüter OM, Schnell E, Verhage M, Tzonopoulos T, Nicoll RA, Janz R, Malenka RC, Geppert M, Südhof TC. Schlüter OM, et al. J Neurosci. 1999 Jul 15;19(14):5834-46. doi: 10.1523/JNEUROSCI.19-14-05834.1999. J Neurosci. 1999. PMID: 10407024 Free PMC article. - A novel function of the C-terminal lipid moieties of Rab3A small G protein implicated in Ca2+-dependent exocytosis--inhibition of interaction with GTP and reduction of this inhibition by phospholipid.
Jin-no Y, Shirataki H, Senbonmatsu T, Yamamoto T, Fujita Y, Nakanishi H, Takai Y. Jin-no Y, et al. Genes Cells. 1997 Apr;2(4):273-88. doi: 10.1111/j.1365-2443.1997.120gc0318.x. Genes Cells. 1997. PMID: 9224661 - Rab3A-rabphilin-3A system in neurotransmitter release.
Sasaki T, Shirataki H, Nakanishi H, Takai Y. Sasaki T, et al. Adv Second Messenger Phosphoprotein Res. 1997;31:279-94. doi: 10.1016/s1040-7952(97)80025-0. Adv Second Messenger Phosphoprotein Res. 1997. PMID: 9344258 Review. No abstract available. - Synaptic vesicle proteins and regulated exocytosis.
Elferink LA, Scheller RH. Elferink LA, et al. J Cell Sci Suppl. 1993;17:75-9. doi: 10.1242/jcs.1993.supplement_17.11. J Cell Sci Suppl. 1993. PMID: 8144706 Review.
Cited by
- tsCRISPR based identification of Rab proteins required for the recycling of Drosophila TRPL ion channel.
Zeger M, Stanisławczyk LS, Bulić M, Binder AM, Huber A. Zeger M, et al. Front Cell Dev Biol. 2024 Sep 20;12:1444953. doi: 10.3389/fcell.2024.1444953. eCollection 2024. Front Cell Dev Biol. 2024. PMID: 39372952 Free PMC article. - Adaptive Changes in Group 2 Metabotropic Glutamate Receptors Underlie the Deficit in Recognition Memory Induced by Methamphetamine in Mice.
Busceti CL, Di Menna L, Castaldi S, D'Errico G, Taddeucci A, Bruno V, Fornai F, Pittaluga A, Battaglia G, Nicoletti F. Busceti CL, et al. eNeuro. 2024 Aug 2;11(8):ENEURO.0523-23.2024. doi: 10.1523/ENEURO.0523-23.2024. Print 2024 Aug. eNeuro. 2024. PMID: 38969501 Free PMC article. - Rabconnectin-3α/DMXL2 Is Locally Enriched at the Synaptic Ribbon of Rod Photoreceptor Synapses.
Dittrich A, Ramesh G, Jung M, Schmitz F. Dittrich A, et al. Cells. 2023 Jun 19;12(12):1665. doi: 10.3390/cells12121665. Cells. 2023. PMID: 37371135 Free PMC article. - Rabphilin 3A binds the N-peptide of SNAP-25 to promote SNARE complex assembly in exocytosis.
Li T, Cheng Q, Wang S, Ma C. Li T, et al. Elife. 2022 Sep 29;11:e79926. doi: 10.7554/eLife.79926. Elife. 2022. PMID: 36173100 Free PMC article. - Feline Adipose Derived Multipotent Stromal Cell Transdifferentiation Into Functional Insulin Producing Cell Clusters.
Taguchi T, Duan W, Wolfson W, Duhon B, Halphen EG, Lopez MJ. Taguchi T, et al. Front Bioeng Biotechnol. 2022 Jun 8;10:904519. doi: 10.3389/fbioe.2022.904519. eCollection 2022. Front Bioeng Biotechnol. 2022. PMID: 35769100 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous