Comparison of dietary calcium with supplemental calcium and other nutrients as factors affecting the risk for kidney stones in women - PubMed (original) (raw)
Comparative Study
Comparison of dietary calcium with supplemental calcium and other nutrients as factors affecting the risk for kidney stones in women
G C Curhan et al. Ann Intern Med. 1997.
Abstract
Background: Calcium intake is believed to play an important role in the formation of kidney stones, but data on the risk factors for stone formation in women are limited.
Objective: To examine the association between intake of dietary and supplemental calcium and the risk for kidney stones in women.
Design: Prospective cohort study with 12-year follow-up.
Setting: Several U.S. states.
Participants: 91,731 women participating in the Nurses' Health Study I who were 34 to 59 years of age in 1980 and had no history of kidney stones.
Measurements: Self-administered food-frequency questionnaires were used to assess diet in 1980, 1984, 1986, and 1990. The main outcome measure was incident symptomatic kidney stones.
Results: During 903,849 person-years of follow-up, 864 cases of kidney stones were documented. After adjustment for potential risk factors, intake of dietary calcium was inversely associated with risk for kidney stones and intake of supplemental calcium was positively associated with risk. The relative risk for stone formation in women in the highest quintile of dietary calcium intake compared with women in the lowest quintile was 0.65 (95% CI, 0.50 to 0.83). The relative risk in women who took supplemental calcium compared with women who did not was 1.20 (CI, 1.02 to 1.41). In 67% of women who took supplemental calcium, the calcium either was not consumed with a meal or was consumed with meals whose oxalate content was probably low. Other dietary factors showed the following relative risks among women in the highest quintile of intake compared with those in the lowest quintile: sucrose, 1.52 (CI, 1.18 to 1.96); sodium, 1.30 (CI, 1.05 to 1.62); fluid, 0.61 (CI, 0.48 to 0.78); and potassium, 0.65 (CI, 0.51 to 0.84).
Conclusions: High intake of dietary calcium appears to decrease risk for symptomatic kidney stones, whereas intake of supplemental calcium may increase risk. Because dietary calcium reduces the absorption of oxalate, the apparently different effects caused by the type of calcium may be associated with the timing of calcium ingestion relative to the amount of oxalate consumed. However, other factors present in dairy products (the major source of dietary calcium) could be responsible for the decreased risk seen with dietary calcium.
Comment in
- Diet and calcium: the end of an era?
Coe FL, Parks JH, Favus MJ. Coe FL, et al. Ann Intern Med. 1997 Apr 1;126(7):553-5. doi: 10.7326/0003-4819-126-7-199704010-00010. Ann Intern Med. 1997. PMID: 9092322 No abstract available. - Calcium intake and kidney stones in women.
Heaney RP. Heaney RP. Ann Intern Med. 1997 Nov 1;127(9):846. doi: 10.7326/0003-4819-127-9-199711010-00015. Ann Intern Med. 1997. PMID: 9382410 No abstract available.
Similar articles
- Dietary factors and the risk of incident kidney stones in younger women: Nurses' Health Study II.
Curhan GC, Willett WC, Knight EL, Stampfer MJ. Curhan GC, et al. Arch Intern Med. 2004 Apr 26;164(8):885-91. doi: 10.1001/archinte.164.8.885. Arch Intern Med. 2004. PMID: 15111375 - Dietary factors and the risk of incident kidney stones in men: new insights after 14 years of follow-up.
Taylor EN, Stampfer MJ, Curhan GC. Taylor EN, et al. J Am Soc Nephrol. 2004 Dec;15(12):3225-32. doi: 10.1097/01.ASN.0000146012.44570.20. J Am Soc Nephrol. 2004. PMID: 15579526 - Beverage use and risk for kidney stones in women.
Curhan GC, Willett WC, Speizer FE, Stampfer MJ. Curhan GC, et al. Ann Intern Med. 1998 Apr 1;128(7):534-40. doi: 10.7326/0003-4819-128-7-199804010-00003. Ann Intern Med. 1998. PMID: 9518397 - Dietary treatment of urinary risk factors for renal stone formation. A review of CLU Working Group.
Prezioso D, Strazzullo P, Lotti T, Bianchi G, Borghi L, Caione P, Carini M, Caudarella R, Ferraro M, Gambaro G, Gelosa M, Guttilla A, Illiano E, Martino M, Meschi T, Messa P, Miano R, Napodano G, Nouvenne A, Rendina D, Rocco F, Rosa M, Sanseverino R, Salerno A, Spatafora S, Tasca A, Ticinesi A, Travaglini F, Trinchieri A, Vespasiani G, Zattoni F; CLU Working Group. Prezioso D, et al. Arch Ital Urol Androl. 2015 Jul 7;87(2):105-20. doi: 10.4081/aiua.2015.2.105. Arch Ital Urol Androl. 2015. PMID: 26150027 Review. - Risk of Kidney Stones: Influence of Dietary Factors, Dietary Patterns, and Vegetarian-Vegan Diets.
Ferraro PM, Bargagli M, Trinchieri A, Gambaro G. Ferraro PM, et al. Nutrients. 2020 Mar 15;12(3):779. doi: 10.3390/nu12030779. Nutrients. 2020. PMID: 32183500 Free PMC article. Review.
Cited by
- Urolithiasis in children: medical approach.
Copelovitch L. Copelovitch L. Pediatr Clin North Am. 2012 Aug;59(4):881-96. doi: 10.1016/j.pcl.2012.05.009. Epub 2012 Jun 15. Pediatr Clin North Am. 2012. PMID: 22857835 Free PMC article. Review. - Dietary and lifestyle factors for primary prevention of nephrolithiasis: a systematic review and meta-analysis.
Lin BB, Lin ME, Huang RH, Hong YK, Lin BL, He XJ. Lin BB, et al. BMC Nephrol. 2020 Jul 11;21(1):267. doi: 10.1186/s12882-020-01925-3. BMC Nephrol. 2020. PMID: 32652950 Free PMC article. - Extraskeletal benefits and risks of calcium, vitamin D and anti-osteoporosis medications.
Body JJ, Bergmann P, Boonen S, Devogelaer JP, Gielen E, Goemaere S, Kaufman JM, Rozenberg S, Reginster JY. Body JJ, et al. Osteoporos Int. 2012 Feb;23 Suppl 1(Suppl 1):S1-23. doi: 10.1007/s00198-011-1891-8. Epub 2012 Feb 4. Osteoporos Int. 2012. PMID: 22311111 Free PMC article. - Gout and Diet: A Comprehensive Review of Mechanisms and Management.
Zhang Y, Chen S, Yuan M, Xu Y, Xu H. Zhang Y, et al. Nutrients. 2022 Aug 26;14(17):3525. doi: 10.3390/nu14173525. Nutrients. 2022. PMID: 36079783 Free PMC article. Review. - Demographic, dietary, and urinary factors and 24-h urinary calcium excretion.
Taylor EN, Curhan GC. Taylor EN, et al. Clin J Am Soc Nephrol. 2009 Dec;4(12):1980-7. doi: 10.2215/CJN.02620409. Epub 2009 Oct 9. Clin J Am Soc Nephrol. 2009. PMID: 19820135 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical