Differential regulation of HIV-1 fusion cofactor expression by CD28 costimulation of CD4+ T cells - PubMed (original) (raw)

. 1997 Apr 11;276(5310):273-6.

doi: 10.1126/science.276.5310.273.

J L Riley, B L Levine, Y Feng, S Kaushal, D W Ritchey, W Bernstein, O S Weislow, C R Brown, E A Berger, C H June, D C St Louis

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Differential regulation of HIV-1 fusion cofactor expression by CD28 costimulation of CD4+ T cells

R G Carroll et al. Science. 1997.

Abstract

Activation of CD4(+) T lymphocytes from human immunodeficiency virus-type 1 (HIV-1)-infected donors with immobilized antibodies to CD3 and CD28 induces a virus-resistant state. This effect is specific for macrophage-tropic HIV-1. Transcripts encoding CXCR4/Fusin, the fusion cofactor used by T cell line-tropic isolates, were abundant in CD3/CD28-stimulated cells, but transcripts encoding CCR5, the fusion cofactor used by macrophage-tropic viruses, were not detectable. Thus, CD3/CD28 costimulation induces an HIV-1-resistant phenotype similar to that seen in some highly exposed and HIV-uninfected individuals.

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