Retention of soluble 99mTc-DTPA in the human lung: 24-h postdeposition - PubMed (original) (raw)

Clinical Trial

. 1997 Apr;82(4):1378-82.

doi: 10.1152/jappl.1997.82.4.1378.

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Clinical Trial

Retention of soluble 99mTc-DTPA in the human lung: 24-h postdeposition

W M Foster et al. J Appl Physiol (1985). 1997 Apr.

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Abstract

Clearance of low-molecular-weight solutes, e.g., radiolabeled chelate diethylenetriaminepentaacetate (DTPA), across epithelial surfaces of distal airways and the lung parenchyma is a broadly used technique to assess epithelial integrity. It has been generally assumed that clearance of solute follows a simple first-order process and that DTPA clearance through the respiratory epithelium and into blood and lymphatic channels is complete within a few hours. Using gamma-camera imaging and a radiolabeled aerosol of 99mTc-labeled DTPA, we observed in eight healthy subjects lung retention of radioisotope approximately 24 h postdeposition of the 99mTc-DTPA. Residual lung retention at the 24-h end point averaged 6.0 +/- 1.8 (SD)% of the amount of radioisotope initially deposited in the lung. This suggests that for normal healthy subjects a small amount of the 99mTc radioisotope, either in a dissociated or chelated form, is nonpermeable or slowly cleared from respiratory tisssues.

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