Stoichiometric and steric principles governing repression by nuclear hormone receptors - PubMed (original) (raw)
Comparative Study
. 1997 Apr 1;11(7):835-46.
doi: 10.1101/gad.11.7.835.
Affiliations
- PMID: 9106656
- DOI: 10.1101/gad.11.7.835
Free article
Comparative Study
Stoichiometric and steric principles governing repression by nuclear hormone receptors
I Zamir et al. Genes Dev. 1997.
Free article
Abstract
We have defined two principles of corepressor function that account for differences in transcriptional repression by nuclear hormone receptors (NHRs). First, we have determined that receptor stoichiometry is a crucial determinant of transcriptional repression mediated by the corepressors N-CoR and SMRT. This provides a molecular explanation for the observation that NHRs repress transcription as dimers but not monomers. Second, corepressor function is restricted by steric effects related to DNA binding in a receptor-specific manner. Thus, although N-CoR and SMRT are capable of binding to several NHRs in solution, they are highly selective about receptor binding on DNA, a context that reflects their in vivo function more accurately. These stoichiometric and steric principles govern specific interactions between corepressors and NHRs, thus providing evidence that N-CoR and SMRT do not serve redundant functions but rather contribute to receptor-specific transcriptional repression.
Similar articles
- Characterization of receptor interaction and transcriptional repression by the corepressor SMRT.
Li H, Leo C, Schroen DJ, Chen JD. Li H, et al. Mol Endocrinol. 1997 Dec;11(13):2025-37. doi: 10.1210/mend.11.13.0028. Mol Endocrinol. 1997. PMID: 9415406 - N-CoR-HDAC corepressor complexes: roles in transcriptional regulation by nuclear hormone receptors.
Jones PL, Shi YB. Jones PL, et al. Curr Top Microbiol Immunol. 2003;274:237-68. doi: 10.1007/978-3-642-55747-7_9. Curr Top Microbiol Immunol. 2003. PMID: 12596910 Review. - The specificity of interactions between nuclear hormone receptors and corepressors is mediated by distinct amino acid sequences within the interacting domains.
Cohen RN, Brzostek S, Kim B, Chorev M, Wondisford FE, Hollenberg AN. Cohen RN, et al. Mol Endocrinol. 2001 Jul;15(7):1049-61. doi: 10.1210/mend.15.7.0669. Mol Endocrinol. 2001. PMID: 11435607 - Modulation of thyroid hormone receptor silencing function by co-repressors and a synergizing transcription factor.
Lutz M, Baniahmad A, Renkawitz R. Lutz M, et al. Biochem Soc Trans. 2000;28(4):386-9. Biochem Soc Trans. 2000. PMID: 10961925 Review.
Cited by
- Corepressors: custom tailoring and alterations while you wait.
Goodson M, Jonas BA, Privalsky MA. Goodson M, et al. Nucl Recept Signal. 2005;3:e003. doi: 10.1621/nrs.03003. Epub 2005 Oct 21. Nucl Recept Signal. 2005. PMID: 16604171 Free PMC article. - Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes.
Guan HP, Ishizuka T, Chui PC, Lehrke M, Lazar MA. Guan HP, et al. Genes Dev. 2005 Feb 15;19(4):453-61. doi: 10.1101/gad.1263305. Epub 2005 Jan 28. Genes Dev. 2005. PMID: 15681609 Free PMC article. - An overview of nuclear receptor coregulators involved in cerebellar development.
Nishihara E. Nishihara E. Cerebellum. 2008;7(1):48-59. doi: 10.1007/s12311-008-0018-z. Cerebellum. 2008. PMID: 18418685 Review. - Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily.
Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A. Dressel U, et al. Mol Cell Biol. 1999 May;19(5):3383-94. doi: 10.1128/MCB.19.5.3383. Mol Cell Biol. 1999. PMID: 10207062 Free PMC article. - SMRTε, a corepressor variant, interacts with a restricted subset of nuclear receptors, including the retinoic acid receptors α and β.
Mengeling BJ, Goodson ML, Bourguet W, Privalsky ML. Mengeling BJ, et al. Mol Cell Endocrinol. 2012 Apr 4;351(2):306-16. doi: 10.1016/j.mce.2012.01.006. Epub 2012 Jan 12. Mol Cell Endocrinol. 2012. PMID: 22266197 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials