The N-end rule pathway of protein degradation - PubMed (original) (raw)
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The N-end rule pathway of protein degradation
A Varshavsky. Genes Cells. 1997 Jan.
Free article
Abstract
The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. Similar but distinct versions of the N-end rule operate in all organisms examined, from mammals to fungi and bacteria. In eukaryotes, the N-end rule pathway is a part of the ubiquitin system. Ubiquitin is a 76-residue protein whose covalent conjugation to other proteins plays a role in many biological processes, including cell growth and differentiation. I discuss the current understanding of the N-end rule pathway.
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