Deconstructing the nucleus: global architecture from local interactions - PubMed (original) (raw)

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Deconstructing the nucleus: global architecture from local interactions

W F Marshall et al. Curr Opin Genet Dev. 1997 Apr.

Abstract

Recent advances in fluorescence in situ hybridization and three-dimensional microscopy have revealed a high degree of large-scale order in the nucleus, indicating that the position of each gene within the nucleus is not random. As with any other biological phenomenon, this large-scale organization must ultimately be specified by molecular interactions. Biochemical and molecular investigations have revealed a small set of local molecular-scale interactions that can be used together in a combinatorial fashion to establish a global large-scale nuclear architecture.

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