Angiogenesis and inflammation in ductal carcinoma in situ of the breast - PubMed (original) (raw)
Angiogenesis and inflammation in ductal carcinoma in situ of the breast
A H Lee et al. J Pathol. 1997 Feb.
Abstract
Several recent studies suggest that vascular density may be an independent prognostic indicator in invasive carcinoma of the breast. Increased vascularity has also been shown in ductal carcinoma in situ (DCIS). The prognostic significance of the inflammatory infiltrate in mammary carcinoma is more controversial, but it could affect angiogenesis by releasing angiogenic factors and digesting matrix. Vascularity and inflammation have been studied in 41 examples of pure DCIS, classified using the method of Holland et al. Immunohistochemistry was performed with antibodies to von Willebrand factor, CD3, CD8, CD45RO, CD45RA, CD20, CD68, and c-erB-2. The main pattern of inflammation was clusters of B and T cells situated either adjacent to involved ducts or in the interductal stroma. Typically, these clusters were around vessels with plump endothelium suggestive of high endothelial venules. A less prominent pattern was a diffuse stromal infiltrate of macrophages and T cells. There were two patterns of increased vascularity associated with DCIS: necklaces of vessels close to the involved ducts and vessels arranged diffusely in the interductal stroma. Each pattern of inflammation and of vascularity was graded semi-quantitatively. Increased stromal vascularity was associated with the perivascular clusters of inflammation; both were associated with c-erB-2 expression and extent of the DCIS. Necklaces of vessels were associated with the diffuse inflammation. Perivascular inflammation and c-erB-2 (but neither pattern of vascularity) were associated with poor differentiation of the DCIS. Thus, different patterns of inflammation are associated with different patterns of vessels. The clusters of B and T cells may be recruited via high endothelial venules induced by the DCIS. Cytokines released by the DCIS and/or the inflammatory cells (clusters or diffuse) may stimulate the two patterns of new vessel formation.
Similar articles
- Angiogenesis and expression of thymidine phosphorylase by inflammatory and carcinoma cells in ductal carcinoma in situ of the breast.
Lee AH, Dublin EA, Bobrow LG. Lee AH, et al. J Pathol. 1999 Feb;187(3):285-90. doi: 10.1002/(SICI)1096-9896(199902)187:3<285::AID-PATH238>3.0.CO;2-R. J Pathol. 1999. PMID: 10398080 - Distinct angiogenic patterns are associated with high-grade in situ ductal carcinomas of the breast.
Engels K, Fox SB, Whitehouse RM, Gatter KC, Harris AL. Engels K, et al. J Pathol. 1997 Feb;181(2):207-12. doi: 10.1002/(SICI)1096-9896(199702)181:2<207::AID-PATH758>3.0.CO;2-4. J Pathol. 1997. PMID: 9120727 - Up-regulation of thymidine phosphorylase expression is associated with a discrete pattern of angiogenesis in ductal carcinomas in situ of the breast.
Engels K, Fox SB, Whitehouse RM, Gatter KC, Harris AL. Engels K, et al. J Pathol. 1997 Aug;182(4):414-20. doi: 10.1002/(SICI)1096-9896(199708)182:4<414::AID-PATH897>3.0.CO;2-Q. J Pathol. 1997. PMID: 9306962 - Microvessel density, proliferating activity, p53 and bcl-2 expression in in situ ductal carcinoma of the breast.
Zolota V, Gerokosta A, Melachrinou M, Kominea A, Aletra C, Scopa CD. Zolota V, et al. Anticancer Res. 1999 Jul-Aug;19(4B):3269-74. Anticancer Res. 1999. PMID: 10652623
Cited by
- IBTK Haploinsufficiency Affects the Tumor Microenvironment of Myc-Driven Lymphoma in E-myc Mice.
Vecchio E, Fiume G, Mignogna C, Iaccino E, Mimmi S, Maisano D, Trapasso F, Quinto I. Vecchio E, et al. Int J Mol Sci. 2020 Jan 30;21(3):885. doi: 10.3390/ijms21030885. Int J Mol Sci. 2020. PMID: 32019112 Free PMC article. - Ductal carcinoma in situ of the breast: immune cell composition according to subtype.
Agahozo MC, van Bockstal MR, Groenendijk FH, van den Bosch TPP, Westenend PJ, van Deurzen CHM. Agahozo MC, et al. Mod Pathol. 2020 Feb;33(2):196-205. doi: 10.1038/s41379-019-0331-8. Epub 2019 Aug 2. Mod Pathol. 2020. PMID: 31375764 - Prognostic role of immune infiltrates in breast ductal carcinoma in situ.
Chen XY, Yeong J, Thike AA, Bay BH, Tan PH. Chen XY, et al. Breast Cancer Res Treat. 2019 Aug;177(1):17-27. doi: 10.1007/s10549-019-05272-2. Epub 2019 May 27. Breast Cancer Res Treat. 2019. PMID: 31134489 Review. - High Densities of Tumor-Associated Plasma Cells Predict Improved Prognosis in Triple Negative Breast Cancer.
Yeong J, Lim JCT, Lee B, Li H, Chia N, Ong CCH, Lye WK, Putti TC, Dent R, Lim E, Thike AA, Tan PH, Iqbal J. Yeong J, et al. Front Immunol. 2018 May 30;9:1209. doi: 10.3389/fimmu.2018.01209. eCollection 2018. Front Immunol. 2018. PMID: 29899747 Free PMC article. - Bcl6/p53 expression, macrophages/mast cells infiltration and microvascular density in invasive breast carcinoma.
Tamma R, Ruggieri S, Annese T, Simone G, Mangia A, Rega S, Zito FA, Nico B, Ribatti D. Tamma R, et al. Oncotarget. 2018 Apr 27;9(32):22727-22740. doi: 10.18632/oncotarget.25220. eCollection 2018 Apr 27. Oncotarget. 2018. PMID: 29854311 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Research Materials