The structure and evolution of the HLA--Bw4 and Bw6 antigens - PubMed (original) (raw)
The structure and evolution of the HLA--Bw4 and Bw6 antigens
C J Barnstable et al. Tissue Antigens. 1979 May.
Abstract
The HLA--Bw4 and Bw6 antigenic determinants have been shown to co-migrate with HLA--B determinants on gel-filtration, sucrose density gradient centrifugation and affinity chromatography, using Lens culinaris lectin and antibody against human beta 2 microbulin. These and other published data imply that the HLA--Bw4 and Bw6 determinants reside on the same polypeptide chain as other HLA--B locus determinants. The implications of this in terms of the evolution of cross reacting groups of antigens at the HLA--B locus are discussed.
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