Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene - PubMed (original) (raw)

. 1997 Apr 24;386(6627):796-804.

doi: 10.1038/386796a0.

S L Dickinson, M L Hermiston, R V Tighe, R G Steen, C G Small, E T Stoeckli, K Keino-Masu, M Masu, H Rayburn, J Simons, R T Bronson, J I Gordon, M Tessier-Lavigne, R A Weinberg

Affiliations

• PMID: 9126737
• DOI: 10.1038/386796a0

Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene

A Fazeli et al. Nature. 1997.

Abstract

The DCC (Deleted in colorectal cancer) gene was first identified as a candidate for a tumour-suppressor gene on human chromosome 18q. More recently, in vitro studies in rodents have provided evidence that DCC might function as a receptor for the axonal chemoattractant netrin-1. Inactivation of the murine Dcc gene caused defects in axonal projections that are similar to those observed in netrin-1-deficient mice but did not affect growth, differentiation, morphogenesis or tumorigenesis in mouse intestine. These observations fail to support a tumour-suppressor function for Dcc, but are consistent with the hypothesis that DCC is a component of a receptor for netrin-1.

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