Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection - PubMed (original) (raw)

Clinical Trial

. 1997 May 9;276(5314):960-4.

doi: 10.1126/science.276.5314.960.

D W Notermans, K Staskus, S W Wietgrefe, M Zupancic, K Gebhard, K Henry, Z Q Zhang, R Mills, H McDade, C M Schuwirth, J Goudsmit, S A Danner, A T Haase

Affiliations

• PMID: 9139661
• DOI: 10.1126/science.276.5314.960

Clinical Trial

Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection

W Cavert et al. Science. 1997.

Erratum in

• Science 1997 May 30;276(5317):1321

Abstract

In lymphoid tissue, where human immunodeficiency virus-type 1 (HIV-1) is produced and stored, three-drug treatment with viral protease and reverse transcriptase inhibitors markedly reduced viral burden. This was shown by in situ hybridization and computerized quantitative analysis of serial tonsil biopsies from previously untreated adults. The frequency of productive mononuclear cells (MNCs) initially diminished with a half-life of about 1 day. Surprisingly, the amount of HIV-1 RNA in virus trapped on follicular dendritic cells (FDCs) decreased almost as quickly. After 24 weeks, MNCs with very few copies of HIV-1 RNA per cell were still detectable, as was proviral DNA; however, the amount of FDC-associated virus decreased by >/=3.4 log units. Thus, 6 months of potent therapy controlled active replication and cleared >99.9 percent of virus from the secondary lymphoid tissue reservoir.

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Comment in

• Stubborn AIDS reservoirs vulnerable to new treatments.
  Cohen J. Cohen J. Science. 1997 May 9;276(5314):898-9. doi: 10.1126/science.276.5314.898. Science. 1997. PMID: 9163035 No abstract available.
• Treating AIDS dementia.
  Lipton SA. Lipton SA. Science. 1997 Jun 13;276(5319):1629-30. doi: 10.1126/science.276.5319.1629b. Science. 1997. PMID: 9206820 No abstract available.

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