Tissue-specific selection for different mtDNA genotypes in heteroplasmic mice - PubMed (original) (raw)
Tissue-specific selection for different mtDNA genotypes in heteroplasmic mice
J P Jenuth et al. Nat Genet. 1997 May.
Abstract
Mammalian mitochondrial DNA (mtDNA) is a highly polymorphic, high-copy-number genome that is maternally inherited. New mutations in mtDNA segregate rapidly in the female germline due to a genetic bottleneck in early oogenesis and as a result most individuals are homoplasmic for a single species of mtDNA. Sequence variants thus accumulate along maternal lineages without genetic recombination. Most of the extant variation in mtDNA in mammalian populations has been assumed to be neutral with respect to selection; however, comparisons of the ratio of replacement to silent nucleotide substitutions between species suggest that the evolution of mammalian mtDNA is not strictly neutral. To test directly whether polymorphic mtDNAs behave as neutral variants, we examined the segregation of two different mtDNA genotypes in the tissues of heteroplasmic mice. We find evidence for random genetic drift in some tissues, but in others strong, tissue-specific and age-related, directional selection for different mtDNA genotypes in the same animal. These surprising data suggest that the coding sequence of mtDNA may represent a compromise between the competing demands of different tissues and point to the existence of unknown, tissue-specific nuclear genes important in the interaction between the nuclear and mitochondrial genomes.
Similar articles
- Nuclear genetic control of mitochondrial DNA segregation.
Battersby BJ, Loredo-Osti JC, Shoubridge EA. Battersby BJ, et al. Nat Genet. 2003 Feb;33(2):183-6. doi: 10.1038/ng1073. Epub 2003 Jan 21. Nat Genet. 2003. PMID: 12539044 - Random genetic drift in the female germline explains the rapid segregation of mammalian mitochondrial DNA.
Jenuth JP, Peterson AC, Fu K, Shoubridge EA. Jenuth JP, et al. Nat Genet. 1996 Oct;14(2):146-51. doi: 10.1038/ng1096-146. Nat Genet. 1996. PMID: 8841183 - A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes.
Cree LM, Samuels DC, de Sousa Lopes SC, Rajasimha HK, Wonnapinij P, Mann JR, Dahl HH, Chinnery PF. Cree LM, et al. Nat Genet. 2008 Feb;40(2):249-54. doi: 10.1038/ng.2007.63. Epub 2008 Jan 27. Nat Genet. 2008. PMID: 18223651 - No sex please, we're mitochondria: a hypothesis on the somatic unit of inheritance of mammalian mtDNA.
Jacobs HT, Lehtinen SK, Spelbrink JN. Jacobs HT, et al. Bioessays. 2000 Jun;22(6):564-72. doi: 10.1002/(SICI)1521-1878(200006)22:6<564::AID-BIES9>3.0.CO;2-4. Bioessays. 2000. PMID: 10842310 Review. - [Variation of the mitochondrial genome in the evolution of Drosophila].
Mitrofanov VG, Sorokina SIu, Andrianov BV. Mitrofanov VG, et al. Genetika. 2002 Aug;38(8):1063-77. Genetika. 2002. PMID: 12244691 Review. Russian.
Cited by
- Selection promotes age-dependent degeneration of the mitochondrial genome.
Korotkevich E, Conrad DN, Gartner ZJ, O'Farrell PH. Korotkevich E, et al. bioRxiv [Preprint]. 2024 Sep 28:2024.09.27.615276. doi: 10.1101/2024.09.27.615276. bioRxiv. 2024. PMID: 39386732 Free PMC article. Preprint. - Evolution and maintenance of mtDNA gene content across eukaryotes.
Veeraragavan S, Johansen M, Johnston IG. Veeraragavan S, et al. Biochem J. 2024 Aug 7;481(15):1015-1042. doi: 10.1042/BCJ20230415. Biochem J. 2024. PMID: 39101615 Free PMC article. Review. - Single-mitochondrion sequencing uncovers distinct mutational patterns and heteroplasmy landscape in mouse astrocytes and neurons.
Kadam PS, Yang Z, Lu Y, Zhu H, Atiyas Y, Shah N, Fisher S, Nordgren E, Kim J, Issadore D, Eberwine J. Kadam PS, et al. BMC Biol. 2024 Jul 29;22(1):162. doi: 10.1186/s12915-024-01953-7. BMC Biol. 2024. PMID: 39075589 Free PMC article. - Single-Mitochondrion Sequencing Uncovers Distinct Mutational Patterns and Heteroplasmy Landscape in Mouse Astrocytes and Neurons.
Kadam PS, Yang Z, Lu Y, Zhu H, Atiyas Y, Shah N, Fisher S, Nordgren E, Kim J, Issadore D, Eberwine J. Kadam PS, et al. bioRxiv [Preprint]. 2024 Jun 19:2024.06.13.598906. doi: 10.1101/2024.06.13.598906. bioRxiv. 2024. PMID: 38915628 Free PMC article. Updated. Preprint. - Mitochondrial haplotype and mito-nuclear matching drive somatic mutation and selection throughout ageing.
Serrano IM, Hirose M, Valentine CC, Roesner S, Schmidt E, Pratt G, Williams L, Salk J, Ibrahim S, Sudmant PH. Serrano IM, et al. Nat Ecol Evol. 2024 May;8(5):1021-1034. doi: 10.1038/s41559-024-02338-3. Epub 2024 Feb 15. Nat Ecol Evol. 2024. PMID: 38361161 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources