Fusion of hamster macrophages induced by lectins - PubMed (original) (raw)

Fusion of hamster macrophages induced by lectins

T J Chambers. J Pathol. 1977 Sep.

Abstract

The fusion of hamster peritoneal macrophages by lectins is described. The conditions under which this occurs are very similar to those previously reported using glutaraldehyde-fixed red cells and anti-hamster macrophage serum. Under conditions in which macrophages are brought into contact before interiorisation of surface-bound lectin, fusion results. It is suggested again that in granulomas, binding of endocytosable material to more than one macrophage results in giant cell formation by a mechanism of simultaneous interiorisation.

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