Microbial products induce autoimmune disease by an IL-12-dependent pathway - PubMed (original) (raw)
. 1997 Jun 1;158(11):5087-90.
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- PMID: 9164922
Microbial products induce autoimmune disease by an IL-12-dependent pathway
B M Segal et al. J Immunol. 1997.
Abstract
The development and exacerbation of autoimmune diseases are associated with antecedent infectious illness. Microbial products such as LPS, bacterial DNA, or oligonucleotides containing an unmethylated cytosine-guanine dinucleotide have cytokine modulating properties. These products converted quiescent myelin basic protein-specific T cells into effector cells capable of transferring experimental allergic encephalomyelitis. The disease-promoting properties of the microbial products were solely dependent on their capacity to induce the production of IL-12.
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