Apparent involvement of a multidrug transporter in the fluoroquinolone resistance of Streptococcus pneumoniae - PubMed (original) (raw)

Apparent involvement of a multidrug transporter in the fluoroquinolone resistance of Streptococcus pneumoniae

N N Baranova et al. Antimicrob Agents Chemother. 1997 Jun.

Abstract

A Streptococcus pneumoniae strain selected for resistance to ethidium bromide demonstrated enhanced energy-dependent efflux of this toxic dye. Both the ethidium resistance and the ethidium efflux could be inhibited by the plant alkaloid reserpine. The ethidium-selected cells demonstrated cross-resistance to the fluoroquinolones norfloxacin and ciprofloxacin; this resistance could also be completely reversed by reserpine. Furthermore, reserpine potentiated the susceptibility of wild-type S. pneumoniae to fluoroquinolones and ethidium. The most plausible explanation for these results is that S. pneumoniae, like some other gram-positive bacteria, expresses a reserpine-sensitive multidrug transporter, which may play an important role in both intrinsic and acquired resistances of this pathogen to fluoroquinolone therapy.

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