Drosophila Hox complex downstream targets and the function of homeotic genes - PubMed (original) (raw)
Review
Drosophila Hox complex downstream targets and the function of homeotic genes
Y Graba et al. Bioessays. 1997 May.
Abstract
Hox complex genes are key developmental regulators highly conserved throughout evolution. The encoded proteins share a 60-amino-acid DNA-binding motif, the homeodomain, and function as transcription factors to control axial patterning. An important question concerns the nature and function of genes acting downstream of Hox proteins. This review focuses on Drosophila, as little is known about this question in other organisms. The noticeable progress gained in the field during the past few years has significantly improved our current understanding of how Hox genes control diversified morphogenesis. Here we summarise the strategies deployed to identify Hox target genes and discuss how their function contributes to pattern formation and morphogenesis. The regulation of target genes is also considered with special emphasis on the mechanisms underlying the specificity of action of Hox proteins in the whole animal.
Similar articles
- Shaping segments: Hox gene function in the genomic age.
Hueber SD, Lohmann I. Hueber SD, et al. Bioessays. 2008 Oct;30(10):965-79. doi: 10.1002/bies.20823. Bioessays. 2008. PMID: 18798525 Review. - Comparative analysis of Hox downstream genes in Drosophila.
Hueber SD, Bezdan D, Henz SR, Blank M, Wu H, Lohmann I. Hueber SD, et al. Development. 2007 Jan;134(2):381-92. doi: 10.1242/dev.02746. Epub 2006 Dec 13. Development. 2007. PMID: 17166915 - Beyond homeosis--HOX function in morphogenesis and organogenesis.
Hombría JC, Lovegrove B. Hombría JC, et al. Differentiation. 2003 Oct;71(8):461-76. doi: 10.1046/j.1432-0436.2003.7108004.x. Differentiation. 2003. PMID: 14641327 Review. - Implications of the spatial and temporal regulation of Hox genes on development and evolution.
Castelli-Gair J. Castelli-Gair J. Int J Dev Biol. 1998;42(3):437-44. Int J Dev Biol. 1998. PMID: 9654029 Review. - Target genes of homeodomain proteins.
Mannervik M. Mannervik M. Bioessays. 1999 Apr;21(4):267-70. doi: 10.1002/(SICI)1521-1878(199904)21:4<267::AID-BIES1>3.0.CO;2-C. Bioessays. 1999. PMID: 10377888 Review.
Cited by
- Role of Homeodomain leucine zipper (HD-Zip) IV transcription factors in plant development and plant protection from deleterious environmental factors.
Chew W, Hrmova M, Lopato S. Chew W, et al. Int J Mol Sci. 2013 Apr 12;14(4):8122-47. doi: 10.3390/ijms14048122. Int J Mol Sci. 2013. PMID: 23584027 Free PMC article. Review. - Insect oenocytes: a model system for studying cell-fate specification by Hox genes.
Gould AP, Elstob PR, Brodu V. Gould AP, et al. J Anat. 2001 Jul-Aug;199(Pt 1-2):25-33. doi: 10.1046/j.1469-7580.2001.19910025.x. J Anat. 2001. PMID: 11523826 Free PMC article. Review. - Hox gene Ultrabithorax regulates distinct sets of target genes at successive stages of Drosophila haltere morphogenesis.
Pavlopoulos A, Akam M. Pavlopoulos A, et al. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2855-60. doi: 10.1073/pnas.1015077108. Epub 2011 Jan 31. Proc Natl Acad Sci U S A. 2011. PMID: 21282633 Free PMC article. - The control of trunk Hox specificity and activity by Extradenticle.
Ryoo HD, Mann RS. Ryoo HD, et al. Genes Dev. 1999 Jul 1;13(13):1704-16. doi: 10.1101/gad.13.13.1704. Genes Dev. 1999. PMID: 10398683 Free PMC article. - Global identification of target genes regulated by APETALA3 and PISTILLATA floral homeotic gene action.
Zik M, Irish VF. Zik M, et al. Plant Cell. 2003 Jan;15(1):207-22. doi: 10.1105/tpc.006353. Plant Cell. 2003. PMID: 12509532 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous