Purification of heat shock protein-peptide complexes for use in vaccination against cancers and intracellular pathogens - PubMed (original) (raw)

Review

Purification of heat shock protein-peptide complexes for use in vaccination against cancers and intracellular pathogens

P K Srivastava. Methods. 1997 Jun.

Abstract

This article describes the methods used for the purification of heat shock proteins gp96, hsp90, and hsp70 from murine and human tissues and cell lines. The heat shock proteins purified by the methods described are associated noncovalently with an array of cellular peptides. The use of heat shock protein-peptide complexes for eliciting prophylactic and therapeutic immunity to cancers and infectious diseases is discussed.

PubMed Disclaimer

Similar articles

• Priming of T cells by heat shock protein-peptide complexes as the basis of tumor vaccines.
  Li Z. Li Z. Semin Immunol. 1997 Oct;9(5):315-22. doi: 10.1006/smim.1997.0087. Semin Immunol. 1997. PMID: 9327526 Review.
• Isolation of MHC class I-restricted tumor antigen peptide and its precursors associated with heat shock proteins hsp70, hsp90, and gp96.
  Ishii T, Udono H, Yamano T, Ohta H, Uenaka A, Ono T, Hizuta A, Tanaka N, Srivastava PK, Nakayama E. Ishii T, et al. J Immunol. 1999 Feb 1;162(3):1303-9. J Immunol. 1999. PMID: 9973383
• Methods of purification of heat shock protein-peptide complexes for use as vaccines against cancers and infectious diseases.
  Srivastava PK, Jaikaria NS. Srivastava PK, et al. Methods Mol Biol. 2001;156:175-86. doi: 10.1385/1-59259-062-4:175. Methods Mol Biol. 2001. PMID: 11068759 No abstract available.
• Autologous heat shock protein-peptide complexes for vaccination against cancer: from bench to bedside.
  Hoos A, Levey DL, Lewis JJ. Hoos A, et al. Dev Biol (Basel). 2004;116:109-15; discussion 133-43. Dev Biol (Basel). 2004. PMID: 15603187 Review.
• A novel therapeutic fusion protein vaccine by two different families of heat shock proteins linked with HPV16 E7 generates potent antitumor immunity and antiangiogenesis.
  Liu B, Ye D, Song X, Zhao X, Yi L, Song J, Zhang Z, Zhao Q. Liu B, et al. Vaccine. 2008 Mar 4;26(10):1387-96. doi: 10.1016/j.vaccine.2007.12.034. Epub 2008 Jan 22. Vaccine. 2008. PMID: 18272260

Cited by

• Heat Shock Protein-Peptide and HSP-Based Immunotherapies for the Treatment of Cancer.
  Shevtsov M, Multhoff G. Shevtsov M, et al. Front Immunol. 2016 Apr 29;7:171. doi: 10.3389/fimmu.2016.00171. eCollection 2016. Front Immunol. 2016. PMID: 27199993 Free PMC article. Review.
• Protective role of stress genes.
  Ray PK. Ray PK. Environ Health Perspect. 1998 May;106(5):A217-8. doi: 10.1289/ehp.106-1533107. Environ Health Perspect. 1998. PMID: 9647883 Free PMC article. Review. No abstract available.
• Apoptotic cells deliver processed antigen to dendritic cells for cross-presentation.
  Blachère NE, Darnell RB, Albert ML. Blachère NE, et al. PLoS Biol. 2005 Jun;3(6):e185. doi: 10.1371/journal.pbio.0030185. Epub 2005 Apr 26. PLoS Biol. 2005. PMID: 15839733 Free PMC article.
• Caught with their PAMPs down? The extracellular signalling actions of molecular chaperones are not due to microbial contaminants.
  Henderson B, Calderwood SK, Coates AR, Cohen I, van Eden W, Lehner T, Pockley AG. Henderson B, et al. Cell Stress Chaperones. 2010 Mar;15(2):123-41. doi: 10.1007/s12192-009-0137-6. Cell Stress Chaperones. 2010. PMID: 19731087 Free PMC article. Review.
• Heat-shock protein 90 associates with N-terminal extended peptides and is required for direct and indirect antigen presentation.
  Callahan MK, Garg M, Srivastava PK. Callahan MK, et al. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1662-7. doi: 10.1073/pnas.0711365105. Epub 2008 Jan 23. Proc Natl Acad Sci U S A. 2008. PMID: 18216248 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information