Identification of a chemokine receptor encoded by human cytomegalovirus as a cofactor for HIV-1 entry - PubMed (original) (raw)

Identification of a chemokine receptor encoded by human cytomegalovirus as a cofactor for HIV-1 entry

O Pleskoff et al. Science. 1997.

Abstract

The human cytomegalovirus encodes a beta-chemokine receptor (US28) that is distantly related to the human chemokine receptors CCR5 and CXCR4, which also serve as cofactors for the entry into cells of human immunodeficiency virus-type 1 (HIV-1). Like CCR5, US28 allowed infection of CD4-positive human cell lines by primary isolates of HIV-1 and HIV-2, as well as fusion of these cell lines with cells expressing the viral envelope proteins. In addition, US28 mediated infection by cell line-adapted HIV-1 for which CXCR4 was an entry cofactor.

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• Does a common virus give HIV a helping hand?
  Balter M. Balter M. Science. 1997 Jun 20;276(5320):1794. doi: 10.1126/science.276.5320.1794. Science. 1997. PMID: 9206839 No abstract available.

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