Impairment of visual object-discrimination learning after perirhinal cortex ablation - PubMed (original) (raw)
Impairment of visual object-discrimination learning after perirhinal cortex ablation
M J Buckley et al. Behav Neurosci. 1997 Jun.
Abstract
Eight cynomolgus monkeys learned preoperatively 20 concurrent visual discriminations between pairs of colored shapes presented on a touch screen with 24-hr intertrial intervals. Three then received bilateral perirhinal cortex ablation, and 5 remained controls. The ablated monkeys were severely impaired in reacquiring the preoperatively acquired set, whereas postoperative learning of 20 new discriminations was not significantly affected. The task was then made more difficult. First, the number of foils from which the stimulus had to be selected was increased to 2, 4, 7, and then 14. Second, larger sets of 40, 80, and 160 problems were presented. Both manipulations revealed some significant but relatively mild impairments in the monkeys with ablations. It is suggested that perirhinal cortex ablation impairs the monkey's capacity to identify individual objects, which leads to deficits in both visual-object recognition memory and discrimination learning.
Similar articles
- Learning and transfer of object-reward associations and the role of the perirhinal cortex.
Buckley MJ, Gaffan D. Buckley MJ, et al. Behav Neurosci. 1998 Feb;112(1):15-23. doi: 10.1037//0735-7044.112.1.15. Behav Neurosci. 1998. PMID: 9517812 - Perirhinal cortex ablation impairs visual object identification.
Buckley MJ, Gaffan D. Buckley MJ, et al. J Neurosci. 1998 Mar 15;18(6):2268-75. doi: 10.1523/JNEUROSCI.18-06-02268.1998. J Neurosci. 1998. PMID: 9482811 Free PMC article. Review. - The primate temporal pole: its putative role in object recognition and memory.
Nakamura K, Kubota K. Nakamura K, et al. Behav Brain Res. 1996 May;77(1-2):53-77. doi: 10.1016/0166-4328(95)00227-8. Behav Brain Res. 1996. PMID: 8762159 Review.
Cited by
- Effects of prior knowledge on brain activation and functional connectivity during memory retrieval.
Guo D, Chen H, Wang L, Yang J. Guo D, et al. Sci Rep. 2023 Aug 22;13(1):13650. doi: 10.1038/s41598-023-40966-0. Sci Rep. 2023. PMID: 37608065 Free PMC article. - Lateral entorhinal cortex lesions impair odor-context associative memory in male rats.
Persson BM, Ambrozova V, Duncan S, Wood ER, O'Connor AR, Ainge JA. Persson BM, et al. J Neurosci Res. 2022 Apr;100(4):1030-1046. doi: 10.1002/jnr.25027. Epub 2022 Feb 20. J Neurosci Res. 2022. PMID: 35187710 Free PMC article. - When the ventral visual stream is not enough: A deep learning account of medial temporal lobe involvement in perception.
Bonnen T, Yamins DLK, Wagner AD. Bonnen T, et al. Neuron. 2021 Sep 1;109(17):2755-2766.e6. doi: 10.1016/j.neuron.2021.06.018. Epub 2021 Jul 14. Neuron. 2021. PMID: 34265252 Free PMC article. - Human hippocampal connectivity is stronger in olfaction than other sensory systems.
Zhou G, Olofsson JK, Koubeissi MZ, Menelaou G, Rosenow J, Schuele SU, Xu P, Voss JL, Lane G, Zelano C. Zhou G, et al. Prog Neurobiol. 2021 Jun;201:102027. doi: 10.1016/j.pneurobio.2021.102027. Epub 2021 Feb 25. Prog Neurobiol. 2021. PMID: 33640412 Free PMC article. - Similar time course of fast familiarity and slow recollection processes for recognition memory in humans and macaques.
Wu Z, Kavanova M, Hickman L, Lin F, Buckley MJ. Wu Z, et al. Learn Mem. 2020 Jun 15;27(7):258-269. doi: 10.1101/lm.051342.120. Print 2020 Jul. Learn Mem. 2020. PMID: 32540915 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources