T cell clonal anergy - PubMed (original) (raw)
Review
T cell clonal anergy
R H Schwartz. Curr Opin Immunol. 1997 Jun.
Abstract
Recent experiments have elucidated two molecular mechanisms that may account for the failure of anergic T cell clones to initiate IL-2 gene transcription following TCR stimulation. First, a block has been identified in the ERK and JNK mitogen-activated protein kinase pathways; the block results from a failure to activate p21ras. It leads to reduced induction of c-Fos and JunB proteins and to a failure to form and phosphorylate the activator protein (AP)-1 heterodimers required for IL-2 gene transcriptional activation. Second, repressor molecules (Nil-2-a and a molecule related to AP-1) have been characterized that dominantly inhibit IL-2 gene transcription.
Similar articles
- Control of T lymphocyte signal transduction through clonal anergy.
Fields P, Fitch FW, Gajewski TF. Fields P, et al. J Mol Med (Berl). 1996 Nov;74(11):673-83. doi: 10.1007/s001090050071. J Mol Med (Berl). 1996. PMID: 8956153 Review. - Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells.
Mondino A, Whaley CD, DeSilva DR, Li W, Jenkins MK, Mueller DL. Mondino A, et al. J Immunol. 1996 Sep 1;157(5):2048-57. J Immunol. 1996. PMID: 8757326 - The p38 mitogen-activated protein kinase pathway in activated and anergic Th1 cells.
DeSilva DR, Jones EA, Feeser WS, Manos EJ, Scherle PA. DeSilva DR, et al. Cell Immunol. 1997 Sep 15;180(2):116-23. doi: 10.1006/cimm.1997.1182. Cell Immunol. 1997. PMID: 9341741 - Induction and stability of the anergic phenotype in T cells.
Valdor R, Macian F. Valdor R, et al. Semin Immunol. 2013 Nov 15;25(4):313-20. doi: 10.1016/j.smim.2013.10.010. Epub 2013 Nov 5. Semin Immunol. 2013. PMID: 24211041 Free PMC article. Review.
Cited by
- Intercellular transfer of MHC molecules in T cell alloimmunity and allotransplantation.
Benichou G, Lancia HH. Benichou G, et al. Biomed J. 2024 May 25;47(5):100749. doi: 10.1016/j.bj.2024.100749. Online ahead of print. Biomed J. 2024. PMID: 38797478 Free PMC article. Review. - ERK Inhibition Promotes Engraftment of Allografts by Reprogramming T-Cell Metabolism.
Tan X, Qi C, Zhao X, Sun L, Wu M, Sun W, Gu L, Wang F, Feng H, Huang X, Xie B, Shi Z, Xie P, Wu M, Zhang Y, Chen G. Tan X, et al. Adv Sci (Weinh). 2023 Jun;10(16):e2206768. doi: 10.1002/advs.202206768. Epub 2023 Apr 4. Adv Sci (Weinh). 2023. PMID: 37013935 Free PMC article. - Tolerogenic Dendritic Cell-Based Approaches in Autoimmunity.
Passeri L, Marta F, Bassi V, Gregori S. Passeri L, et al. Int J Mol Sci. 2021 Aug 5;22(16):8415. doi: 10.3390/ijms22168415. Int J Mol Sci. 2021. PMID: 34445143 Free PMC article. Review. - Self and microbiota-derived epitopes induce CD4+ T cell anergy and conversion into CD4+Foxp3+ regulatory cells.
Kuczma MP, Szurek EA, Cebula A, Ngo VL, Pietrzak M, Kraj P, Denning TL, Ignatowicz L. Kuczma MP, et al. Mucosal Immunol. 2021 Mar;14(2):443-454. doi: 10.1038/s41385-020-00349-4. Epub 2020 Nov 2. Mucosal Immunol. 2021. PMID: 33139845 Free PMC article. - The therapeutic potential of bilobalide on experimental autoimmune encephalomyelitis (EAE) mice.
Miao Q, Zhang XX, Han QX, Ren SS, Sui RX, Yu JW, Wang J, Wang Q, Yu JZ, Cao L, Xiao W, Xiao BG, Ma CG. Miao Q, et al. Metab Brain Dis. 2020 Jun;35(5):793-807. doi: 10.1007/s11011-020-00555-w. Epub 2020 Mar 25. Metab Brain Dis. 2020. PMID: 32215835
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous