Targeting the minor groove of DNA - PubMed (original) (raw)
Review
Targeting the minor groove of DNA
D E Wemmer et al. Curr Opin Struct Biol. 1997 Jun.
Abstract
Small molecules that specifically bind with high affinity to any predetermined DNA sequence in the human genome will be useful tools in molecular biology and, potentially, in human medicine. Pairing rules have been developed to control rationally the sequence specificity of minor groove binding polyamides containing N-methylimidazole and N-methylpyrrole amino acids. Using simple molecular shapes and a two-letter aromatic amino acid code, pyrrole-imidazole polyamides achieve affinities and specificities comparable to DNA-binding proteins.
Similar articles
- Pyrrole-imidazole polyamides distinguish between double-helical DNA and RNA.
Chenoweth DM, Meier JL, Dervan PB. Chenoweth DM, et al. Angew Chem Int Ed Engl. 2013 Jan 2;52(1):415-8. doi: 10.1002/anie.201205775. Epub 2012 Sep 14. Angew Chem Int Ed Engl. 2013. PMID: 22987334 Free PMC article. - Recognition of DNA by designed ligands at subnanomolar concentrations.
Trauger JW, Baird EE, Dervan PB. Trauger JW, et al. Nature. 1996 Aug 8;382(6591):559-61. doi: 10.1038/382559a0. Nature. 1996. PMID: 8700233 - On the pairing rules for recognition in the minor groove of DNA by pyrrole-imidazole polyamides.
White S, Baird EE, Dervan PB. White S, et al. Chem Biol. 1997 Aug;4(8):569-78. doi: 10.1016/s1074-5521(97)90243-x. Chem Biol. 1997. PMID: 9281524 - [Advances in the chemical and biological studies of polyamides].
Zhu SL, Gao PH, Li P, Jiang YY, Zhang DZ. Zhu SL, et al. Yao Xue Xue Bao. 2008 Nov;43(11):1089-93. Yao Xue Xue Bao. 2008. PMID: 19239025 Review. Chinese. - Recognition of the DNA minor groove by pyrrole-imidazole polyamides.
Dervan PB, Edelson BS. Dervan PB, et al. Curr Opin Struct Biol. 2003 Jun;13(3):284-99. doi: 10.1016/s0959-440x(03)00081-2. Curr Opin Struct Biol. 2003. PMID: 12831879 Review.
Cited by
- Small-molecule regulators that mimic transcription factors.
Rodríguez-Martínez JA, Peterson-Kaufman KJ, Ansari AZ. Rodríguez-Martínez JA, et al. Biochim Biophys Acta. 2010 Oct-Dec;1799(10-12):768-74. doi: 10.1016/j.bbagrm.2010.08.010. Epub 2010 Sep 6. Biochim Biophys Acta. 2010. PMID: 20804876 Free PMC article. Review. - Protein and drug interactions in the minor groove of DNA.
Morávek Z, Neidle S, Schneider B. Morávek Z, et al. Nucleic Acids Res. 2002 Mar 1;30(5):1182-91. doi: 10.1093/nar/30.5.1182. Nucleic Acids Res. 2002. PMID: 11861910 Free PMC article. - DNA sequence recognition by an isopropyl substituted thiazole polyamide.
James PL, Merkina EE, Khalaf AI, Suckling CJ, Waigh RD, Brown T, Fox KR. James PL, et al. Nucleic Acids Res. 2004 Jun 24;32(11):3410-7. doi: 10.1093/nar/gkh666. Print 2004. Nucleic Acids Res. 2004. PMID: 15247333 Free PMC article. - Transcription factors in the development and treatment of immune disorders.
Patalano SD, Fuxman Bass P, Fuxman Bass JI. Patalano SD, et al. Transcription. 2025 Feb;16(1):118-140. doi: 10.1080/21541264.2023.2294623. Epub 2023 Dec 15. Transcription. 2025. PMID: 38100543 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources