Assessment of vitamin A status by the deuterated-retinol-dilution technique and comparison with hepatic vitamin A concentration in Bangladeshi surgical patients - PubMed (original) (raw)

Clinical Trial

Assessment of vitamin A status by the deuterated-retinol-dilution technique and comparison with hepatic vitamin A concentration in Bangladeshi surgical patients

M J Haskell et al. Am J Clin Nutr. 1997 Jul.

Erratum in

Am J Clin Nutr 1999 Mar;69(3):576

Abstract

Hepatic stores of vitamin A were estimated in 31 Bangladeshi surgical patients (15 males and 16 females) by the deuterated-retinol-dilution (DRD) technique and by analysis of the vitamin A concentration of a liver biopsy specimen obtained during previously scheduled abdominal surgery. Patients ranged in age from 21 to 65 y and had an average body mass index (BMI: in kg/m2) of 17.7 +/- 3.4. They received 0.753 mumol [2H4]retinyl acetate/kg body wt orally 9-11 d before surgery. Hepatic vitamin A reserves were estimated according to Furr et al (Am J Clin Nutr 1989;49:713-6) by using a single plasma isotopic-ratio measurement (18-25 d postdose). Estimated mean hepatic vitamin A stores were similar by both techniques, 0.110 +/- 0.072 mmol (by DRD) compared with 0.100 +/- 0.067 mmol (by biopsy). Regression analysis was used to compare results of the DRD and biopsy techniques. A significant linear relation was found between the two techniques (r = 0.75, P < 0.0001), and the least-squares regression line was not significantly different from y = x (P = 0.09). The results indicate that the DRD technique provided a very good estimate of hepatic vitamin A reserves for this population. However, a wide prediction interval was observed for estimates of hepatic vitamin A reserves for individual subjects. Thus, further refinement of the prediction model is necessary to improve estimates of hepatic vitamin A reserves for individual subjects.

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Comment in

Isotope-dilution techniques: a wave of the future in human nutrition.
Olson JA. Olson JA. Am J Clin Nutr. 1997 Jul;66(1):186-7. doi: 10.1093/ajcn/66.1.186. Am J Clin Nutr. 1997. PMID: 9209189 No abstract available.
Correcting for vitamin A turnover in isotope-dilution studies.
Olson JA. Olson JA. Am J Clin Nutr. 1999 Mar;69(3):576-7. doi: 10.1093/ajcn/69.3.576. Am J Clin Nutr. 1999. PMID: 10075351 No abstract available.

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Assessment of vitamin A status by the deuterated-retinol-dilution technique and comparison with hepatic vitamin A concentration in Bangladeshi surgical patients - PubMed (original) (raw)