Regulation of gene expression by fatty acids: special reference to fatty acid-binding protein (FABP) - PubMed (original) (raw)
Regulation of gene expression by fatty acids: special reference to fatty acid-binding protein (FABP)
I Niot et al. Biochimie. 1997 Feb-Mar.
Abstract
During the last years, the direct involvement of lipidic nutrients in the regulation of genes has been established. Fatty acids may induce or repress the transcription rate of several genes involved in both lipid and carbohydrate metabolisms. Gene up-regulation has been found in various tissues including liver, adipose tissue and small intestine. It is only triggered by saturated and unsaturated long-chain fatty acids or their CoA-derivatives. In contrast, gene down-regulation appears to be restricted to the liver. This negative effect is exerted only by polyunsaturated fatty acids. Long-chain fatty acids are able to regulate the expression of two different genes oppositely in the same cell type. The molecular mechanism of these fatty acid-mediated effects remains unclear. The involvement of members of the peroxisome proliferator-activated receptor is discussed.
Similar articles
- Regulation of gene expression in adipose cells by polyunsaturated fatty acids.
Bernlohr DA, Coe NR, Simpson MA, Hertzel AV. Bernlohr DA, et al. Adv Exp Med Biol. 1997;422:145-56. doi: 10.1007/978-1-4757-2670-1_12. Adv Exp Med Biol. 1997. PMID: 9361822 - Comparison of dose-response relationships for induction of lipid metabolizing and growth regulatory genes by peroxisome proliferators in rat liver.
Belury MA, Moya-Camarena SY, Sun H, Snyder E, Davis JW, Cunningham ML, Vanden Heuvel JP. Belury MA, et al. Toxicol Appl Pharmacol. 1998 Aug;151(2):254-61. doi: 10.1006/taap.1998.8443. Toxicol Appl Pharmacol. 1998. PMID: 9707502 - Fatty acid regulation of fatty acid-binding protein expression in the small intestine.
Poirier H, Niot I, Degrace P, Monnot MC, Bernard A, Besnard P. Poirier H, et al. Am J Physiol. 1997 Aug;273(2 Pt 1):G289-95. doi: 10.1152/ajpgi.1997.273.2.G289. Am J Physiol. 1997. PMID: 9277406 - Liver fatty acid binding protein and mitogenesis in transfected hepatoma cells.
Keler T, Khan S, Sorof S. Keler T, et al. Adv Exp Med Biol. 1997;400A:517-24. doi: 10.1007/978-1-4615-5325-0_70. Adv Exp Med Biol. 1997. PMID: 9547599 Review. No abstract available. - Role of membrane-associated and cytoplasmic fatty acid-binding proteins in cellular fatty acid metabolism.
Glatz JF, van Nieuwenhoven FA, Luiken JJ, Schaap FG, van der Vusse GJ. Glatz JF, et al. Prostaglandins Leukot Essent Fatty Acids. 1997 Oct;57(4-5):373-8. doi: 10.1016/s0952-3278(97)90413-0. Prostaglandins Leukot Essent Fatty Acids. 1997. PMID: 9430381 Review.
Cited by
- Intestinal mucosal adaptation.
Drozdowski L, Thomson AB. Drozdowski L, et al. World J Gastroenterol. 2006 Aug 7;12(29):4614-27. doi: 10.3748/wjg.v12.i29.4614. World J Gastroenterol. 2006. PMID: 16937429 Free PMC article. Review. - Differential involvement of peroxisome-proliferator-activated receptors alpha and delta in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestine.
Poirier H, Niot I, Monnot MC, Braissant O, Meunier-Durmort C, Costet P, Pineau T, Wahli W, Willson TM, Besnard P. Poirier H, et al. Biochem J. 2001 Apr 15;355(Pt 2):481-8. doi: 10.1042/0264-6021:3550481. Biochem J. 2001. PMID: 11284737 Free PMC article. - Effects of linoleic acid and eicosapentaenoic acid on cell proliferation and lipid-metabolism gene expression in primary duck hepatocytes.
Liu WM, Shi FX, Lu LZ, Zhang C, Liu YL, Zhang J, Tao ZR, Shen JD, Li GQ, Wang DQ, Li JJ, Tian Y. Liu WM, et al. Mol Cell Biochem. 2011 Jun;352(1-2):19-24. doi: 10.1007/s11010-011-0735-3. Epub 2011 Jan 28. Mol Cell Biochem. 2011. PMID: 21274596 - Polyunsaturated fatty acid regulation of gene expression.
Ntambi JM, Bené H. Ntambi JM, et al. J Mol Neurosci. 2001 Apr-Jun;16(2-3):273-8; discussion 279-84. doi: 10.1385/JMN:16:2-3:273. J Mol Neurosci. 2001. PMID: 11478382 Review. - Long chain fatty acids as modulators of gene transcription in preadipose cells.
Grimaldi PA, Teboul L, Gaillard D, Armengod AV, Amri EZ. Grimaldi PA, et al. Mol Cell Biochem. 1999 Feb;192(1-2):63-8. Mol Cell Biochem. 1999. PMID: 10331659 Review.