Carcinogenesis: a balance between beta-catenin and APC - PubMed (original) (raw)
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Carcinogenesis: a balance between beta-catenin and APC
B M Gumbiner. Curr Biol. 1997.
Free article
Abstract
A protein first identified by its association with cadherin cell adhesion molecules, beta-catenin, has been implicated in carcinogenesis. In a number of different types of cancer, signalling through beta-catenin is upregulated either by direct mutation of beta-catenin or loss of negative regulation by the APC tumor suppressor protein.
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