The mouse Clock mutation behaves as an antimorph and maps within the W19H deletion, distal of Kit - PubMed (original) (raw)
The mouse Clock mutation behaves as an antimorph and maps within the W19H deletion, distal of Kit
D P King et al. Genetics. 1997 Jul.
Abstract
Clock is a semidominant mutation identified from an N-ethyl-N-nitrosourea mutagenesis screen in mice. Mice carrying the Clock mutation exhibit abnormalities of circadian behavior, including lengthening of endogenous period and loss of rhythmicity. To identify the gene affected by this mutation, we have generated a high-resolution genetic map (> 1800 meioses) of the Clock locus. We report that Clock is 0.7 cM distal of Kit on mouse chromosome 5. Mapping shows that Clock lies within the W19H deletion. Complementation analysis of different Clock and W19H compound genotypes indicates that the Clock mutation behaves as an antimorph. This antimorphic behavior of Clock strongly argues that Clock defines a gene centrally involved in the mammalian circadian system.
Similar articles
- Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior.
Vitaterna MH, King DP, Chang AM, Kornhauser JM, Lowrey PL, McDonald JD, Dove WF, Pinto LH, Turek FW, Takahashi JS. Vitaterna MH, et al. Science. 1994 Apr 29;264(5159):719-25. doi: 10.1126/science.8171325. Science. 1994. PMID: 8171325 Free PMC article. - Structural analysis of chromosomal rearrangements associated with the developmental mutations Ph, W19H, and Rw on mouse chromosome 5.
Nagle DL, Martin-DeLeon P, Hough RB, Bućan M. Nagle DL, et al. Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7237-41. doi: 10.1073/pnas.91.15.7237. Proc Natl Acad Sci U S A. 1994. PMID: 8041773 Free PMC article. - Keeping time without a clock.
Collins B, Blau J. Collins B, et al. Neuron. 2006 May 4;50(3):348-50. doi: 10.1016/j.neuron.2006.04.022. Neuron. 2006. PMID: 16675389 Review. - Molecular cogs of the insect circadian clock.
Shirasu N, Shimohigashi Y, Tominaga Y, Shimohigashi M. Shirasu N, et al. Zoolog Sci. 2003 Aug;20(8):947-55. doi: 10.2108/zsj.20.947. Zoolog Sci. 2003. PMID: 12951399 Review.
Cited by
- Metabolism and the circadian clock converge.
Eckel-Mahan K, Sassone-Corsi P. Eckel-Mahan K, et al. Physiol Rev. 2013 Jan;93(1):107-35. doi: 10.1152/physrev.00016.2012. Physiol Rev. 2013. PMID: 23303907 Free PMC article. Review. - The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase-response curve amplitude.
Vitaterna MH, Ko CH, Chang AM, Buhr ED, Fruechte EM, Schook A, Antoch MP, Turek FW, Takahashi JS. Vitaterna MH, et al. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9327-32. doi: 10.1073/pnas.0603601103. Epub 2006 Jun 5. Proc Natl Acad Sci U S A. 2006. PMID: 16754844 Free PMC article. - Regulation of dental enamel shape and hardness.
Simmer JP, Papagerakis P, Smith CE, Fisher DC, Rountrey AN, Zheng L, Hu JC. Simmer JP, et al. J Dent Res. 2010 Oct;89(10):1024-38. doi: 10.1177/0022034510375829. Epub 2010 Jul 30. J Dent Res. 2010. PMID: 20675598 Free PMC article. Review. - Impaired steroidogenesis and implantation failure in Bmal1-/- mice.
Ratajczak CK, Boehle KL, Muglia LJ. Ratajczak CK, et al. Endocrinology. 2009 Apr;150(4):1879-85. doi: 10.1210/en.2008-1021. Epub 2008 Dec 4. Endocrinology. 2009. PMID: 19056819 Free PMC article. - Deficiency of circadian protein CLOCK reduces lifespan and increases age-related cataract development in mice.
Dubrovsky YV, Samsa WE, Kondratov RV. Dubrovsky YV, et al. Aging (Albany NY). 2010 Dec;2(12):936-44. doi: 10.18632/aging.100241. Aging (Albany NY). 2010. PMID: 21149897 Free PMC article.
References
- Proc Natl Acad Sci U S A. 1971 Sep;68(9):2112-6 - PubMed
- J Biol Rhythms. 1994 Winter;9(3-4):189-216 - PubMed
- Genet Res. 1984 Oct;44(2):161-8 - PubMed
- Proc Natl Acad Sci U S A. 1987 Feb;84(3):784-8 - PubMed
- Nature. 1987 Mar 26-Apr 1;326(6111):390-2 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases