Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease - PubMed (original) (raw)
Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease
S Minoshima et al. Ann Neurol. 1997 Jul.
Free article
Abstract
This study investigated cerebral glucose metabolism in very early Alzheimer's disease, before a clinical diagnosis of probable Alzheimer's disease is possible, using [18F]fluorodeoxyglucose positron emission tomography. First, 66 patients with probable Alzheimer's disease with a spectrum of dementia severity (Mini-Mental State Examination score, 0-23) were recruited and studied. Cortical metabolic activity was analyzed topographically using three-dimensional stereotactic surface projections. Regression analysis was performed for each brain pixel to predict metabolic patterns of very early disease. Predictions were tested prospectively in a group of 8 patients who complained only of memory impairment without general cognitive decline (Mini-Mental State Examination score, 25 +/- 1) at the time of scanning but whose condition later progressed to probable Alzheimer's disease. Both results were compared to cerebral metabolic activity in 22 age-similar normal control subjects. Prediction and analysis of actual patients consistently indicated marked metabolic reduction (21-22%) in the posterior cingulate cortex and cinguloparietal transitional area in patients with very early Alzheimer's disease. Mean metabolic reduction in the posterior cingulate cortex was significantly greater than that in the lateral neocortices or parahippocampal cortex. The result suggests a functional importance for the posterior cingulate cortex in impairment of learning and memory, which is a feature of very early Alzheimer's disease.
Similar articles
- Cerebral metabolic differences in Parkinson's and Alzheimer's diseases matched for dementia severity.
Vander Borght T, Minoshima S, Giordani B, Foster NL, Frey KA, Berent S, Albin RL, Koeppe RA, Kuhl DE. Vander Borght T, et al. J Nucl Med. 1997 May;38(5):797-802. J Nucl Med. 1997. PMID: 9170449 - Activation in the premotor cortex during mental calculation in patients with Alzheimer's disease: relevance of reduction in posterior cingulate metabolism.
Ouchi Y, Yoshikawa E, Futatsubashi M, Okada H, Torizuka T, Kaneko M. Ouchi Y, et al. Neuroimage. 2004 May;22(1):155-63. doi: 10.1016/j.neuroimage.2003.12.035. Neuroimage. 2004. PMID: 15110005 - Longitudinal PET Evaluation of Cerebral Metabolic Decline in Dementia: A Potential Outcome Measure in Alzheimer's Disease Treatment Studies.
Alexander GE, Chen K, Pietrini P, Rapoport SI, Reiman EM. Alexander GE, et al. Am J Psychiatry. 2002 May;159(5):738-45. doi: 10.1176/appi.ajp.159.5.738. Am J Psychiatry. 2002. PMID: 11986126 - Positron emission tomography in patients with clinically diagnosed Alzheimer's disease.
McGeer PL, Kamo H, Harrop R, Li DK, Tuokko H, McGeer EG, Adam MJ, Ammann W, Beattie BL, Calne DB, et al. McGeer PL, et al. CMAJ. 1986 Mar 15;134(6):597-607. CMAJ. 1986. PMID: 3512063 Free PMC article. Review. - Cerebral blood flow and metabolic abnormalities in Alzheimer's disease.
Matsuda H. Matsuda H. Ann Nucl Med. 2001 Apr;15(2):85-92. doi: 10.1007/BF02988596. Ann Nucl Med. 2001. PMID: 11448080 Review.
Cited by
- Brain Glucose Metabolism in Health, Obesity, and Cognitive Decline-Does Insulin Have Anything to Do with It? A Narrative Review.
Rebelos E, Rinne JO, Nuutila P, Ekblad LL. Rebelos E, et al. J Clin Med. 2021 Apr 6;10(7):1532. doi: 10.3390/jcm10071532. J Clin Med. 2021. PMID: 33917464 Free PMC article. Review. - Functional connectivity of white matter as a biomarker of cognitive decline in Alzheimer's disease.
Gao Y, Sengupta A, Li M, Zu Z, Rogers BP, Anderson AW, Ding Z, Gore JC; Alzheimer’s Disease Neuroimaging Initiative. Gao Y, et al. PLoS One. 2020 Oct 16;15(10):e0240513. doi: 10.1371/journal.pone.0240513. eCollection 2020. PLoS One. 2020. PMID: 33064765 Free PMC article. - Associations between biomarkers and age in the presenilin 1 E280A autosomal dominant Alzheimer disease kindred: a cross-sectional study.
Fleisher AS, Chen K, Quiroz YT, Jakimovich LJ, Gutierrez Gomez M, Langois CM, Langbaum JB, Roontiva A, Thiyyagura P, Lee W, Ayutyanont N, Lopez L, Moreno S, Muñoz C, Tirado V, Acosta-Baena N, Fagan AM, Giraldo M, Garcia G, Huentelman MJ, Tariot PN, Lopera F, Reiman EM. Fleisher AS, et al. JAMA Neurol. 2015 Mar;72(3):316-24. doi: 10.1001/jamaneurol.2014.3314. JAMA Neurol. 2015. PMID: 25580592 Free PMC article. - Distribution of microglial phenotypes as a function of age and Alzheimer's disease neuropathology in the brains of people with Down syndrome.
Martini AC, Helman AM, McCarty KL, Lott IT, Doran E, Schmitt FA, Head E. Martini AC, et al. Alzheimers Dement (Amst). 2020 Oct 14;12(1):e12113. doi: 10.1002/dad2.12113. eCollection 2020. Alzheimers Dement (Amst). 2020. PMID: 33088896 Free PMC article. - Functional connectivity in cortical regions in dementia with Lewy bodies and Alzheimer's disease.
Kenny ER, Blamire AM, Firbank MJ, O'Brien JT. Kenny ER, et al. Brain. 2012 Feb;135(Pt 2):569-81. doi: 10.1093/brain/awr327. Epub 2011 Dec 20. Brain. 2012. PMID: 22189566 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical