FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis - PubMed (original) (raw)

. 1997 Jul 25;272(30):18542-5.

doi: 10.1074/jbc.272.30.18542.

M Ahmad, S Ottilie, F Bullrich, S Banks, Y Wang, T Fernandes-Alnemri, C M Croce, G Litwack, K J Tomaselli, R C Armstrong, E S Alnemri

Affiliations

• PMID: 9228018
• DOI: 10.1074/jbc.272.30.18542

Free article

FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis

S M Srinivasula et al. J Biol Chem. 1997.

Free article

Abstract

We identified and cloned a novel human protein that contains FADD/Mort1 death effector domain homology regions, designated FLAME-1. FLAME-1, although most similar in structure to Mch4 and Mch5, does not possess caspase activity but can interact specifically with FADD, Mch4, and Mch5. Interestingly, FLAME-1 is recruited to the Fas receptor complex and can abrogate Fas/TNFR-induced apoptosis upon expression in FasL/tumor necrosis factor-sensitive MCF-7 cells, possibly by acting as a dominant-negative inhibitor. These findings identify a novel endogenous control point that regulates Fas/TNFR1-mediated apoptosis.

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