Conformational disease - PubMed (original) (raw)
Review
Conformational disease
R W Carrell et al. Lancet. 1997.
Abstract
Several diverse disorders, including the prevalent dementias and encephalopathies, are now believed to arise from the same general disease mechanism. In each, there is abnormal unfolding and then aggregation of an underlying protein. The gradual accumulation of these aggregates and the acceleration of their formation by stress explain the characteristic late or episodic onset of the clinical disease. The understanding of these processes at the molecular level is opening prospects of more rational approaches to investigation and therapy.
Comment in
- What happens when mutant neuroserpins get into bad shape.
Miller RJ, Roos RP. Miller RJ, et al. Lancet. 2000 Feb 19;355(9204):590-1. doi: 10.1016/S0140-6736(99)00457-2. Lancet. 2000. PMID: 10696974 No abstract available.
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